Document Detail


Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized.
MedLine Citation:
PMID:  21075313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether melanoma is hierarchically organized into phenotypically distinct subpopulations of tumorigenic and nontumorigenic cells or whether most melanoma cells retain tumorigenic capacity, irrespective of their phenotype. We found 28% of single melanoma cells obtained directly from patients formed tumors in NOD/SCID IL2Rγ(null) mice. All stage II, III, and IV melanomas obtained directly from patients had common tumorigenic cells. All tumorigenic cells appeared to have unlimited tumorigenic capacity on serial transplantation. We were unable to find any large subpopulation of melanoma cells that lacked tumorigenic potential. None of 22 heterogeneously expressed markers, including CD271 and ABCB5, enriched tumorigenic cells. Some melanomas metastasized in mice, irrespective of whether they arose from CD271(-) or CD271(+) cells. Many markers appeared to be reversibly expressed by tumorigenic melanoma cells.
Authors:
Elsa Quintana; Mark Shackleton; Hannah R Foster; Douglas R Fullen; Michael S Sabel; Timothy M Johnson; Sean J Morrison
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer cell     Volume:  18     ISSN:  1878-3686     ISO Abbreviation:  Cancer Cell     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2010-12-16     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  510-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Howard Hughes Medical Institute.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation
Humans
Melanoma / metabolism,  pathology*
Mice
Mice, Inbred NOD
Mice, SCID
Naphthalenes / metabolism
Neoplasm Metastasis
P-Glycoprotein / metabolism
Phenotype*
Transplantation, Heterologous / pathology
Tumor Markers, Biological / metabolism
Grant Support
ID/Acronym/Agency:
CA46592/CA/NCI NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/ABCB5 protein, human; 0/Naphthalenes; 0/P-Glycoprotein; 0/Tumor Markers, Biological; 1L4806J2QF/adapalene
Comments/Corrections

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