| Phenotypes and environmental factors: their influence in PCOS. | |
| | |
MedLine Citation:
|
PMID: 22229564 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Polycystic ovary syndrome (PCOS) is a complex syndrome of unclear etiopathogenesis characterized by heterogeneity in phenotypic manifestations. The clinical phenotype of PCOS includes reproductive and hormonal aberrations, namely anovulation and hyperandrogenism, which coexist with metabolic disturbances. Reflecting the crosstalk between the reproductive system and metabolic tissues, obesity not only deteriorates the metabolic profile but also aggravates ovulatory dysfunction and hyperandrogenism. Although the pathogenesis of PCOS remains unclear ,the syndrome appears to involve environmental and genetic components. Starting from early life and extending throughout lifecycle, environmental insults may affect susceptible women who finally demonstrate the clinical phenotype of PCOS. Diet emerges as the major environmental determinant of PCOS .Overnutrition leading to obesity is widely recognized to have an aggravating impact , while another detrimental dietary factor may be the high content of food in advanced glycated end products (AGEs) .Environmental exposure to industrial products ,particularly Bisphenol A(BPA), may also exacerbate the clinical course of PCOS. AGEs and BPA may act as endocrine disruptors in the pathogenesis of the syndrome. PCOS appears to mirror the harmful influence of the modern environment on the reproductive and metabolic balance of inherently predisposed individuals. |
| | |
Authors:
|
Evanthia Diamanti-Kandarakis; Charikleia Christakou; Evangelos Marinakis |
Related Documents
:
|
21473704 - The role of immunotherapy in guillain-barré syndrome: understanding the mechanism of a... 21791604 - Analysis of human syndromes with disordered chromatin reveals the impact of heterochrom... 22022094 - Diuretic loading test and use of bartter's normogram in diagnosing a case of gitelman's... 10752584 - Sign language tics in a prelingually deaf man. 9711164 - Linburg syndrome. 1584354 - Protrusio acetabuli in neurofibromatosis: nondysplastic and dysplastic forms. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
|
Title: Current pharmaceutical design Volume: - ISSN: 1873-4286 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Third Department of Internal Medicine, Medical School, University of Athens , Sotiria General Hospital ,Mesogion Avenue 152, Athens 11527, Greece. e.diamanti.kandarakis@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Unveiling mRNA changes during meiotic progression and pre-implantation development: help from large ...
Next Document: Stem Cells in Adult Human Ovaries: from Female Fertility to Ovarian Cancer.