Document Detail

Phenotypes of atopic dermatitis.
MedLine Citation:
PMID:  21054785     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis (AD) is a common disease affecting both children and adults. AD develops from a complex interplay between environmental, genetic, immunologic and biochemical factors. Genetic factors predispose atopic subjects to mount exaggerated Th2 responses and to a poorly efficient epidermal barrier, which may be sufficient to initiate inflammation in the skin and may favor allergic sensitization. Thus AD can present with different clinical pheno-types. AD is classically distinguished into an intrinsic and extrinsic form, which are clinically identical but the former lacks high level specific IgE and is not associated with respiratory atopy. Although in many cases AD presents with monotonous eczematous lesions on the face, neck and skin folds, it may also present with other features. Very common is nummular eczema, which in many instances may be the dominant expression of AD. In other patients, AD affects limited areas (periorificial eczema, nipple eczema, cheilitis, hand eczema) or its main presentation is with excoriated papules and nodules (atopic prurigo). In conclusion, AD is a multifaceted disease affecting patients with epidermal barrier dysfunction and dry and sensitive skin. The recognition of the less common AD phenotypes is essential for proper patient management.
Silvia Pugliarello; Alessandra Cozzi; Paolo Gisondi; Giampiero Girolomoni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-04
Journal Detail:
Title:  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG     Volume:  9     ISSN:  1610-0387     ISO Abbreviation:  J Dtsch Dermatol Ges     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-04-18     Revised Date:  2011-05-10    
Medline Journal Info:
Nlm Unique ID:  101164708     Medline TA:  J Dtsch Dermatol Ges     Country:  Germany    
Other Details:
Languages:  eng; ger     Pagination:  12-20     Citation Subset:  IM    
Copyright Information:
© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.
Department of Medicine, Section of Dermatology and Venereology, University of Verona, Italy.
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MeSH Terms
Dermatitis, Atopic / classification*,  diagnosis*
Diagnosis, Differential
Terminology as Topic*
Comment In:
J Dtsch Dermatol Ges. 2011 Apr;9(4):339   [PMID:  21439019 ]

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