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Phenotype analysis and the molecular mechanism of enamel hypoplasia
MedLine Citation:
PMID:  19221580     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Enamel hypoplasia is a surface defect of the tooth crown caused by a disturbance of enamel matrix secretion. Enamel hypoplasia may be inherited, or result from illness, malnutrition, trauma, or high concentrations of fluorides or strontium in the drinking water or food. Different types of enamel hypoplasia have been distinguished, such as pit-type, plane-type, and linear enamel hypoplasia. Hypoplasia has been related to the intensity and duration of stress events, the number of affected ameloblasts, and their position along the forming tooth crown. Amelogenesis imperfecta (AI) is a heterogeneous group of inherited defects in dental enamel formation, most teeth are affected in both the primary and permanent dentition. The malformed enamel can be unusually thin, soft, rough and stained. The strict definition of AI includes only those cases where enamel defects occur in the absence of other symptoms. Currently, there are seven candidate genes for AI: amelogenin, enamelin, ameloblastin, tuftelin, distal-less homeobox 3, enamelysin, and kallikrein 4. Since the enamel is formed according to a strict chronological sequence, and once formed, undergoes no repair or regeneration. Then the analysis the phenotype of enamel hypoplasia can provide insights of the severity of inherited or environmental stress and the molecular mechanism during the period of enamel formation.
Authors:
Ping Lv; Xue-jun Gao
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences     Volume:  41     ISSN:  1671-167X     ISO Abbreviation:  Beijing Da Xue Xue Bao     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125284     Medline TA:  Beijing Da Xue Xue Bao     Country:  China    
Other Details:
Languages:  chi     Pagination:  121-3     Citation Subset:  IM    
Affiliation:
Department of Endodontic and Operative Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China.
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