Document Detail

Phenotype analysis of Saccharomyces cerevisiae mutants with deletions in Pir cell wall glycoproteins.
MedLine Citation:
PMID:  18278564     Owner:  NLM     Status:  MEDLINE    
Proteins with internal repeats (Pir) belong to a minor group of covalently linked yeast cell wall proteins. They are not essential for viability but important for cell wall strength, reduced permeability against plant antifungal enzymes and maintenance of osmotic stability. Here we show the importance of Pir proteins of Saccharomyces cerevisiae for growth at low pH and in presence of various inhibitors. Cell wall analysis of Deltapir1,2,3,4 deletion strain revealed slightly increased chitin content and changes in relative proportion of alkali-soluble and insoluble glucan and chitin fractions. Activation of the cell wall integrity pathway was indicated by increased levels of double phosphorylated Mpk1p/Slt2p in the pir deletants.
Marián Mazán; Katarína Mazánová; Vladimír Farkas
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-16
Journal Detail:
Title:  Antonie van Leeuwenhoek     Volume:  94     ISSN:  0003-6072     ISO Abbreviation:  Antonie Van Leeuwenhoek     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-09-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372625     Medline TA:  Antonie Van Leeuwenhoek     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  335-42     Citation Subset:  IM    
Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, 84538 Bratislava, Slovakia.
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MeSH Terms
Cell Wall / genetics,  metabolism*
Chitin / metabolism
Fungal Proteins / genetics,  metabolism
Gene Expression Regulation, Fungal
Glucans / metabolism
Glycoproteins / genetics,  metabolism*
Heat-Shock Proteins / genetics,  metabolism
Mitogen-Activated Protein Kinases / metabolism
Saccharomyces cerevisiae / genetics,  growth & development,  metabolism*
Saccharomyces cerevisiae Proteins / genetics,  metabolism*
Sequence Deletion*
Reg. No./Substance:
0/Fungal Proteins; 0/Glucans; 0/Glycoproteins; 0/HSP150 protein, S cerevisiae; 0/Heat-Shock Proteins; 0/PIR1 protein, S cerevisiae; 0/Pir3 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; 0/ccw5 protein, S cerevisiae; 1398-61-4/Chitin; EC Protein Kinases; EC protein, S cerevisiae

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