Document Detail

Phenothiazine-associated apnea in two siblings.
MedLine Citation:
PMID:  2028629     Owner:  NLM     Status:  MEDLINE    
A two-month-old white girl presented to our facility with increasing lethargy and new onset apnea and bradycardia following a week of upper respiratory tract infection symptoms. The patient had been receiving a cough syrup containing promethazine hydrochloride during the previous five days, which was temporally correlated with the onset of lethargy and apneic episodes. Upon further investigation, it was discovered that the patient's older sibling also may have experienced phenothiazine-associated apnea after receiving a combination of meperidine hydrochloride, promethazine hydrochloride, and chlorpromazine as a premedication prior to an endoscopic examination. In addition to the presentation of these cases, the literature pertaining to phenothiazine-associated apnea is reviewed.
M L Buck; J L Blumer
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  DICP : the annals of pharmacotherapy     Volume:  25     ISSN:  1042-9611     ISO Abbreviation:  DICP     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-06-12     Completed Date:  1991-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904338     Medline TA:  DICP     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  IM    
Department of Pharmacy, University of Virginia Health Sciences Center, Charlottesville 22908.
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MeSH Terms
Apnea / chemically induced*,  drug therapy
Bradycardia / chemically induced
Chlorpromazine / adverse effects
Drug Therapy, Combination
Meperidine / adverse effects
Naloxone / therapeutic use
Phenothiazines / adverse effects*
Promethazine / adverse effects
Urinary Tract Infections / complications
Reg. No./Substance:
0/Phenothiazines; 465-65-6/Naloxone; 50-53-3/Chlorpromazine; 57-42-1/Meperidine; 60-87-7/Promethazine; 92-84-2/phenothiazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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