Document Detail

Phenomenon of the adaptive stabilization of sarcoplasmic and nuclear structures in myocardium.
MedLine Citation:
PMID:  1781765     Owner:  NLM     Status:  MEDLINE    
In adaptation of rats to repeated stress exposure, a mechanism gradually forms at the level of heart to provide a considerable increase in the organ resistance to reperfusion paradox and toxic concentrations of catecholamines and Ca2+. Sarcoplasmic reticulum and mitochondria isolated from the hearts of adapted animals are highly resistant to autolysis, and nuclei to the damaging action of one-chain DNA. These changes are named phenomenon of the adaptive stabilization of structures (PhASS). An important role of myocardial heat shock protein (HSP) accumulation in the mechanism of PhASS is shown. The development of PhASS is accompanied by an increased resistance of myocardium to ischemic necrosis.
F Z Meerson; Malyshev IYu; A B Shneider
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  86 Suppl 3     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  205-14     Citation Subset:  IM; S    
Institute of General Pathology and Pathological Physiology of the USSR AMS, Moscow.
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MeSH Terms
Adaptation, Physiological
Calcium / metabolism*,  pharmacology
Intracellular Membranes / drug effects
Myocardial Reperfusion Injury / prevention & control*
Myocardium / metabolism*
Rats, Inbred Strains
Stress, Physiological
Reg. No./Substance:

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