| Phenomenological features and clinical impact of affective disorders in OCD: a focus on the bipolar disorder and OCD connection. | |
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MedLine Citation:
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PMID: 22109969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Given the general population prevalence rates of obsessive compulsive disorder (OCD) and the affective disorders, one would expect the co-occurrence of these syndromes to be rare. Yet findings by our group and others have revealed extremely high rates of comorbidity in OCD with both depressive disorders (DD; 50%) and bipolar disorder (BPD; 10%). The current investigation sought to further clarify the role affective disorder comorbidity-particularly that with BPD-may play in the clinical expression of OCD. METHOD: A total of 605 individuals with OCD were evaluated with the Structured Clinical Interview for DSM-IV. The sample included three groups: BPD (bipolar I or II; N = 79, 13.1%), DD (major depression or dysthymia; N = 388, 64.1%), and NAD (no affective disorder comorbidity; N = 138, 22.8%). Group-wise comparisons were conducted on comorbidity patterns, impairment measures, and clinical features of OCD. RESULTS: Analyses revealed a graded severity pattern, with the BPD group as the most severe, followed by the DD group, and finally the NAD group. Severity was reflected by the total number of Axis I disorders (P<.01), the number of psychiatric hospitalizations (P<.001), impairment measures (Ps<.05), and OCD symptoms (P<.01). It is worth noting that the impairment and OCD symptom severity findings were not attributable to the higher level of nonmood disorder comorbidities in the BPD and DD groups. RESULTS: Those individuals with comorbid affective disorders, particularly BPD, represent a clinically severe group compared to those without such comorbidity. Clarifying the phenomenological features of OCD-affective disorder comorbidity has important etiological and treatment implications. |
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Authors:
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Kiara R Timpano; Liza M Rubenstein; Dennis L Murphy |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Intramural Date: 2011-11-22 |
Journal Detail:
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Title: Depression and anxiety Volume: 29 ISSN: 1520-6394 ISO Abbreviation: Depress Anxiety Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-04-18 Completed Date: 2012-08-30 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 9708816 Medline TA: Depress Anxiety Country: United States |
Other Details:
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Languages: eng Pagination: 226-33 Citation Subset: IM |
Copyright Information:
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© 2011 Wiley Periodicals, Inc. |
Affiliation:
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University of Miami, Coral Gables, Florida 33146, USA. kiaratimpano@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Bipolar Disorder / classification, epidemiology* Comorbidity Depressive Disorder / epidemiology* Female Humans Male Middle Aged Obsessive-Compulsive Disorder / epidemiology* Predictive Value of Tests Prevalence Psychiatric Status Rating Scales Severity of Illness Index Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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Z01 MH000336-28/MH/NIMH NIH HHS; Z01 MH000336-29/MH/NIMH NIH HHS; ZIA MH000336-30/MH/NIMH NIH HHS; ZIA MH000336-31/MH/NIMH NIH HHS; ZIA MH000336-32/MH/NIMH NIH HHS |
| Comments/Corrections | |
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