Document Detail


Phenolsulfonphthalein pharmacokinetics and renal morphologic changes in adult pony mares with gentamicin-induced nephrotoxicosis.
MedLine Citation:
PMID:  2619115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in renal function, determined by pharmacokinetics of phenolsulfonphthalein (PSP), and renal morphologic features were examined in adult pony mares given 20 mg of gentamicin sulfate/kg of body weight, IV, q 8 h (group A) n = 7 or isotonic saline solution, IV, q 8 h, n = 5 (group B) for 14 days. Susceptibility of ponies to gentamicin-induced nephrotoxicosis was varied. Two group-A ponies developed acute renal failure and were euthanatized before treatment day 14, whereas 5 group-A A ponies did not develop physical or behavioral abnormalities after 14 days of gentamicin administration. All group-A ponies but none of group-B ponies developed ultrastructural abnormalities of the proximal tubular epithelium, consistent with gentamicin-induced nephrotoxicosis. Significant (P less than 0.05) differences were not detected in pharmacokinetic values of either group. Clearance of PSP was reduced in 4 group-A ponies that developed the most severe gentamicin-induced nephrotoxicosis. Changes in clearance of PSP were significantly (P less than 0.05) correlated with changes in the serum creatinine concentration.
Authors:
K W Hinchcliff; S M McGuirk; P S MacWilliams; A J Cooley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  50     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-03-06     Completed Date:  1990-03-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1848-53     Citation Subset:  IM    
Affiliation:
Department of Medical Science, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
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MeSH Terms
Descriptor/Qualifier:
Animals
Epithelium / drug effects,  pathology,  ultrastructure
Female
Gentamicins / toxicity*
Horses / metabolism*
Kidney / drug effects*,  metabolism,  pathology,  ultrastructure
Kidney Tubules, Proximal / drug effects,  pathology,  ultrastructure
Microscopy, Electron
Necrosis
Phenolphthaleins / pharmacokinetics*
Phenolsulfonphthalein / pharmacokinetics*
Random Allocation
Chemical
Reg. No./Substance:
0/Gentamicins; 0/Phenolphthaleins; 143-74-8/Phenolsulfonphthalein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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