Document Detail


Phenolic acids are absorbed from the rat stomach with different absorption rates.
MedLine Citation:
PMID:  17002419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intestinal absorption characteristics of phenolic acids (PAs) have been elucidated in terms of their affinity for the monocarboxylic acid transporter (MCT). Recently, the involvement of the stomach has been implicated in the absorption of polyphenols. The present work demonstrates that the gastric absorption efficiency of each PA is apparently different between various PAs. Various PAs with different affinities for MCT were administered (2.25 mumol) to rat stomach, and then the plasma concentration of the PA was measured. The plasma concentration of ferulic acid (FA) peaked 5 min after administration in the stomach. At 5 min after administration, the plasma concentration of each PA increased in the order: gallic acid = chlorogenic acid < caffeic acid < p-coumaric acid = FA. This order matches their respective affinity for MCT in Caco-2 cells, which we have demonstrated in previous studies. These results indicated that MCT might be involved in the gastric absorption of PAs, similar to the intestinal absorption.
Authors:
Yutaka Konishi; Zhaohui Zhao; Makoto Shimizu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  54     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-27     Completed Date:  2006-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7539-43     Citation Subset:  IM    
Affiliation:
Central Laboratories for Frontier Technology, Kirin Brewery Co., Ltd., Yokohama-shi, Kanagawa 236-0004, Japan. konishiy@kirin.co.jp
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MeSH Terms
Descriptor/Qualifier:
Absorption
Acids, Carbocyclic / blood,  pharmacokinetics*
Animals
Aorta, Abdominal
Coumaric Acids / blood,  pharmacokinetics
Kinetics
Male
Monocarboxylic Acid Transporters / metabolism
Portal Vein
Rats
Rats, Wistar
Stomach / metabolism*
Chemical
Reg. No./Substance:
0/Acids, Carbocyclic; 0/Coumaric Acids; 0/Monocarboxylic Acid Transporters; 1135-24-6/ferulic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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