Document Detail

Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects.
MedLine Citation:
PMID:  14756917     Owner:  NLM     Status:  MEDLINE    
Tea and coffee are rich in polyphenols with a variety of biological activities. Many of the demonstrated activities are consistent with favourable effects on the risk of chronic diseases. 4-O-methylgallic acid (4OMGA) and isoferulic acid are potential biomarkers of exposure to polyphenols derived from tea and coffee respectively. 4OMGA is derived from gallic acid in tea, and isoferulic acid is derived from chlorogenic acid in coffee. Our major objective was to explore the relationships of tea and coffee intake with 24 h urinary excretion of 4OMGA and isoferulic acid in human subjects. The relationships of long-term usual (111 participants) and contemporaneously recorded current (344 participants) tea and coffee intake with 24 h urinary excretion of 4OMGA and isoferulic acid were assessed in two populations. 4OMGA was related to usual (r 0.50, P<0.001) and current (r 0.57, P<0.001) tea intake, and isoferulic acid was related to usual (r 0.26, P=0.008) and current (r 0.18, P<0.001) coffee intake. Overall, our present results are consistent with the proposal that 4OMGA is a good biomarker for black tea-derived polyphenol exposure, but isoferulic acid may be of limited usefulness as a biomarker for coffee-derived polyphenol exposure.
Jonathan M Hodgson; Shin Yee Chan; Ian B Puddey; Amanda Devine; Naiyana Wattanapenpaiboon; Mark L Wahlqvist; Widjaja Lukito; Valerie Burke; Natalie C Ward; Richard L Prince; Kevin D Croft
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  91     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-03-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
University of Western Australia School of Medicine and Pharmacology, Royal Perth Hospital, Perth, Western Australia, Australia.
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MeSH Terms
Biological Markers / urine
Case-Control Studies
Cinnamates / urine
Coffee / chemistry*
Cross-Sectional Studies
Flavonoids / administration & dosage*
Gallic Acid / analogs & derivatives*,  urine
Hydroxybenzoic Acids / metabolism*
Middle Aged
Phenols / administration & dosage*
Tea / chemistry*
Reg. No./Substance:
0/Biological Markers; 0/Cinnamates; 0/Coffee; 0/Flavonoids; 0/Hydroxybenzoic Acids; 0/Phenols; 0/Tea; 0/polyphenols; 149-91-7/Gallic Acid; 29656-58-4/phenolic acid; 4319-02-2/3,5-dihydroxy-4-methoxybenzoic acid; 537-73-5/isoferulic acid

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