Document Detail

Phenol sympathectomy in the treatment of intermittent claudication: a controlled clinical trail.
MedLine Citation:
PMID:  1089438     Owner:  NLM     Status:  MEDLINE    
Twenty-five patients with intermittent claudication were randomly allocated to treatment either by injection of phenol into the lumbar sympathetic chain or by injection of local anaesthetic subcutaneously. On the day after the injection, sympathectomy, assessed by skin temperature change, was achieved in 85 per cent of the phenol group. At 1 month subjective improvement was claimed by 45 per cent of the patients in the sympathectomized group and by 64 per cent in the control group; at 3 months the figures were 25 and 45 per cent respectively. Treadmill testing at two exercise loads showed no significant difference in claudication distance or stopping time between the two groups. Calf blood pressure response following exercise was not affected by sympathectomy. There is no subjective or objective evidence that phenol sympathectomy improves intermittent claudication.
T Fyfe; R O Quin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of surgery     Volume:  62     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-05-09     Completed Date:  1975-05-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  68-71     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Clinical Trials as Topic
Injections, Subcutaneous
Intermittent Claudication / drug therapy,  therapy*
Leg / blood supply
Lidocaine / therapeutic use
Middle Aged
Phenols / administration & dosage,  therapeutic use*
Physical Exertion
Skin Temperature
Sympathetic Nervous System*
Reg. No./Substance:
0/Phenols; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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