| Phenobarbitone-induced urinary excretions of D-glucaric acid and 6beta-hydroxycortisol in man. | |
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MedLine Citation:
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PMID: 991005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The urinary excretion of D-glucaric acid and 6beta-hydroxycortisol were determined in normal subjects before, during, and after 14 days treatment with placebo or phenobarbitone. The excretion of both metabolites was significantly potentiated by phenobarbitone and returned to baseline values 1 month after treatment was withdrawn. It was suggested that the determination of urinary D-glucaric acid reflects the activity of the hepatic microsomal mixed function oxidase system after the administration of an inducing agent such as phenobarbitone. |
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Authors:
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A N Latham; P Turner; C Franklin; W Maclay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 54 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1976 Oct |
Date Detail:
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Created Date: 1977-01-28 Completed Date: 1977-01-28 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 778-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Glucaric Acid / urine* Humans Hydrocortisone / analogs & derivatives*, urine Male Middle Aged Phenobarbital / pharmacology* Placebos Sugar Acids / urine* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 0/Sugar Acids; 25525-21-7/Glucaric Acid; 50-06-6/Phenobarbital; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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