Document Detail


Phenobarbital treatments lower DDT body burden in rhesus monkeys.
MedLine Citation:
PMID:  7259297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Decreased DDT, DDD, DDE in blood and DDA in urine followed phenobarbital treatments (10 mg/kg/day, 11 days, intramuscular (im)) in three male rhesus monkeys (Macaca mulatta). Animals were fed DDT diets containing up to 500 ppm DDT during a 3-year period. Induction of liver monooxygenases was confirmed by reduced in vivo antipyrine plasma half-life and increased in vitro oxidation rates of dihydroisodrin, p-nitroanisole and benz(alpha)pyrene by homogenates of liver obtained from closed needle biopsy. Chlorohydrocarbon blood levels significantly decreased during the induction period (days 1-11). Concentrations on day 28 were at or below pre-DDT exposure levels. Urine DDA gradually decreased in all monkeys from days 16 to 28.
Authors:
P W Ferguson; C R Clark; S J Gee; R I Krieger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of environmental contamination and toxicology     Volume:  10     ISSN:  0090-4341     ISO Abbreviation:  Arch. Environ. Contam. Toxicol.     Publication Date:  1981  
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0357245     Medline TA:  Arch Environ Contam Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  263-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Burden
DDT / analogs & derivatives,  blood,  metabolism*,  urine
Dichlorodiphenyl Dichloroethylene / blood
Dichlorodiphenyldichloroethane / blood
Enzyme Induction / drug effects
Liver / drug effects*
Macaca mulatta
Male
Phenobarbital / pharmacology*
Grant Support
ID/Acronym/Agency:
ES00054/ES/NIEHS NIH HHS; ES00125/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
50-06-6/Phenobarbital; 50-29-3/DDT; 72-54-8/Dichlorodiphenyldichloroethane; 72-55-9/Dichlorodiphenyl Dichloroethylene; 83-05-6/bis(p-chlorophenyl)acetic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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