Document Detail

Pheniformin in insulin-dependent diabetics.
MedLine Citation:
PMID:  4914612     Owner:  NLM     Status:  MEDLINE    
Forty-one diabetic patients on insulin were given 100mg. of phenformin daily for six weeks, either before or after a period of six weeks of inert capsules, in a double-blind cross-over trial. Eleven patients while on phenformin noticed hypoglycaemic effects and reduced their insulin on average by almost 20% without resultant rise in blood sugar levels. Twenty-eight patients felt no untoward effects and maintained their usual insulin dose. Phenformin led to improved control of the diabetes, with a significant decrease in blood sugar levels and a significant reduction in the variability of the weekly blood sugar readings. There was no increased ketosis, no change in cholesterol, and no significant loss of weight.
A Bloom; R J Kole
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1970 Mar 
Date Detail:
Created Date:  1970-09-10     Completed Date:  1970-09-10     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  660-2     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Glucose
Cholesterol / blood
Clinical Trials as Topic
Diabetes Mellitus / drug therapy*
Insulin / administration & dosage,  therapeutic use
Middle Aged
Phenformin / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 114-86-3/Phenformin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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