Document Detail


Phenformin-induced hypoglycaemia in normal subjects.
MedLine Citation:
PMID:  5780431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Study of the effect of phenformin on the blood glucose level in normal subjects before and during 70 hours of starvation showed a statistically significant hypoglycaemic effect after 40 hours of starvation. This effect was not due to increased glucose utilization.Another finding in this study was a statistically significant decrease in total urinary nitrogen excretion during starvation in subjects given phenformin. These findings show that the hypoglycaemic effect of phenformin in starved normal subjects is due to inhibition of gluconeogenesis.
Authors:
J Lyngsoe; J Trap-Jensen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  2     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1969 Apr 
Date Detail:
Created Date:  1969-06-05     Completed Date:  1969-06-05     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  224-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose*
Gluconeogenesis / drug effects*
Glucose Tolerance Test
Humans
Male
Nitrogen / urine
Phenformin / pharmacology*
Starvation*
Chemical
Reg. No./Substance:
0/Blood Glucose; 114-86-3/Phenformin; 7727-37-9/Nitrogen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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