Document Detail


Phenethylamines in brain and liver of rats with experimentally induced phenylketonuria-like characteristics.
MedLine Citation:
PMID:  4269184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Phenethylamines were extracted from brain and liver of rats with phenylketonuria-like characteristics produced in vivo by inhibition of phenylalanine hydroxylase (EC 1.14.3.1) with p-chlorophenylalanine, with or without phenylalanine administration. To protect amines against oxidation by monoamine oxidase, pargyline was also administered. 2. beta-Phenethylamine was the major compound found in brain and liver. beta-Phenethanolamine and octopamine were also present, in lesser amounts, and the concentrations of these three amines paralleled blood phenylalanine concentrations. By comparison, tissues from control animals had only very low concentrations of these amines. 3. Small amounts of normetadrenaline, m-tyramine and 3-methoxytyramine were also found. 4. The inhibitors used, p-chlorophenylalanine and pargyline, gave rise to p-chlorophenethylamine and benzylamine respectively, the first via decarboxylation, the second probably by breakdown during extraction. 5. Distribution of phenethylamines in different brain regions and in subcellular fractions of rat brain cells was also investigated. The content of phenethylamine was highest in the striatum. 6. These findings are discussed in the light of changes occurring in human patients with uncontrolled phenylketonuria.
Authors:
D J Edwards; K Blau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  132     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1973 Jan 
Date Detail:
Created Date:  1973-10-09     Completed Date:  1973-10-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology,  metabolism*
Centrifugation, Density Gradient
Chromatography, Gas
Ethanolamines / metabolism
Fenclonine
Humans
Liver / cytology,  metabolism*
Male
Mental Retardation / etiology
Pargyline / pharmacology
Phenethylamines / biosynthesis*
Phenylalanine Hydroxylase / antagonists & inhibitors
Phenylketonurias / complications,  metabolism
Rats
Subcellular Fractions / metabolism
Chemical
Reg. No./Substance:
0/Ethanolamines; 0/Phenethylamines; 555-57-7/Pargyline; 7424-00-2/Fenclonine; EC 1.14.16.1/Phenylalanine Hydroxylase
Comments/Corrections

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