Document Detail


Phencyclidine during pregnancy: fetal brain levels and neurobehavioral effects.
MedLine Citation:
PMID:  3226378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Either phencyclidine (PCP) (5, 10, or 20 mg/kg) or saline was administered SC to pregnant CF-1 mice during either MID (E6-E15) or LATE (E12-E18) gestation. Because of the reported prolonged persistence of PCP in adult tissues we first determined its half-life in fetal brain for both treatment periods. PCP appeared rapidly in fetal tissues after maternal administration but was not detected after 8 hours. Then, other treated and control litters were fostered to untreated controls, growth determined and the ontogeny of isolation-induced aggressive behavior examined. Subteratogenic doses of PCP produced mild maternal toxicity without lethality. There was an apparent selective embryolethal effect on males but PCP did not produce an effect on postnatal growth. Prenatal PCP did not alter the ontogeny or intensity of isolation-induced aggressive behavior in male offspring. The results are discussed in relation to other prenatal studies of PCP toxicity and teratogenicity.
Authors:
T A Fico; C Vanderwende
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  10     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1989-03-29     Completed Date:  1989-03-29     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
Affiliation:
Rutgers, State University of New Jersey, Department of Pharmacology and Toxicology, Piscataway 08854.
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MeSH Terms
Descriptor/Qualifier:
Aggression / drug effects*
Animals
Body Weight / drug effects
Female
Fetus / drug effects,  metabolism*
Male
Phencyclidine / pharmacokinetics*,  toxicity
Pregnancy
Prenatal Exposure Delayed Effects*
Rats
Social Isolation
Grant Support
ID/Acronym/Agency:
1 31F DA05273/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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