| Phenanthrylalkanoic acids, IV: Syntheses and antiinflammatory activity of 2-, 3-, and 9-phenanthryl- and 9-chloro-3-phenanthryl derivatives of propanoic acid. | |
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MedLine Citation:
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PMID: 2360869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The phenanthrylethanols 2a-d were obtained by reduction of the acetyl derivatives 1a-d and converted, through the phenanthrylethyl halides 3a-d and 4b, into the nitriles 5a-d, whose acid hydrolysis afforded the acids of the title, 6a-d. The antiinflammatory activity of these acids was measured on the carrageenin-induced edema and found as 1/3 (6a), 1/43 (6b), 1/5 (6c), and 1/7 (6d) of that of fenbufen. |
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Authors:
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F Fernández; C González; G Gómez; C López; L Medina; J M Calleja; E Cano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archiv der Pharmazie Volume: 323 ISSN: 0365-6233 ISO Abbreviation: Arch. Pharm. (Weinheim) Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-08-02 Completed Date: 1990-08-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0330167 Medline TA: Arch Pharm (Weinheim) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 239-42 Citation Subset: IM |
Affiliation:
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Departmento de Química Organica, Facultad de Farmacia, Universidad de Santiago, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis* Carrageenan Chemical Phenomena Chemistry Edema / chemically induced, drug therapy Male Phenanthrenes / chemical synthesis*, pharmacology Propionates / chemical synthesis* Propionic Acids / chemical synthesis*, pharmacology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Phenanthrenes; 0/Propionates; 0/Propionic Acids; 9000-07-1/Carrageenan |
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