Document Detail


Phenanthrylalkanoic acids, IV: Syntheses and antiinflammatory activity of 2-, 3-, and 9-phenanthryl- and 9-chloro-3-phenanthryl derivatives of propanoic acid.
MedLine Citation:
PMID:  2360869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The phenanthrylethanols 2a-d were obtained by reduction of the acetyl derivatives 1a-d and converted, through the phenanthrylethyl halides 3a-d and 4b, into the nitriles 5a-d, whose acid hydrolysis afforded the acids of the title, 6a-d. The antiinflammatory activity of these acids was measured on the carrageenin-induced edema and found as 1/3 (6a), 1/43 (6b), 1/5 (6c), and 1/7 (6d) of that of fenbufen.
Authors:
F Fernández; C González; G Gómez; C López; L Medina; J M Calleja; E Cano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archiv der Pharmazie     Volume:  323     ISSN:  0365-6233     ISO Abbreviation:  Arch. Pharm. (Weinheim)     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-08-02     Completed Date:  1990-08-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0330167     Medline TA:  Arch Pharm (Weinheim)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  239-42     Citation Subset:  IM    
Affiliation:
Departmento de Química Organica, Facultad de Farmacia, Universidad de Santiago, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
Carrageenan
Chemical Phenomena
Chemistry
Edema / chemically induced,  drug therapy
Male
Phenanthrenes / chemical synthesis*,  pharmacology
Propionates / chemical synthesis*
Propionic Acids / chemical synthesis*,  pharmacology
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Phenanthrenes; 0/Propionates; 0/Propionic Acids; 9000-07-1/Carrageenan

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