| Phasic menstrual cycle effects on the control of breathing in healthy women. | |
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MedLine Citation:
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PMID: 16542884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the effects of menstrual cycle phase on ventilatory control. Fourteen eumenorrheic women were studied in the early follicular (FP; 1-6 days) and mid-luteal (LP; 20-24 days) phase of the menstrual cycle. Blood for the determination of arterial PCO(2) (PaCO(2)) , plasma strong ion difference ([SID]), progesterone ([P(4)]), and 17beta-estradiol ([E(2)]) concentrations were obtained at rest. Subjects performed a CO(2) rebreathing procedure that included prior hyperventilation and maintenance of iso-oxia to evaluate central and peripheral chemoreflex, and nonchemoreflex drives to breathe. Resting PaCO(2) and [SID] were lower; minute ventilation (V (E)), [P(4)] and [E(2)] were higher in the LP versus FP. Within the LP, significant correlations were observed for PaCO(2) with [P(4)], [E(2)] and [SID]. Menstrual cycle phase had no effect on the threshold or sensitivity of the central and/or peripheral ventilatory chemoreflex response to CO(2). Both (V (E)) and the ventilatory response to hypocapnia (representing nonchemoreflex drives to breathe) were approximately 1L/min greater in the LP versus FP accounting for the reduction in PaCO(2) . These data support the hypothesis that phasic menstrual cycle changes in PaCO(2) may be due, at least in part, to the stimulatory effects of [P(4)], [E(2)] and [SID] on ventilatory drive. |
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Authors:
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Lubomira Slatkovska; Dennis Jensen; Gregory A L Davies; Larry A Wolfe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-15 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 154 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-22 Completed Date: 2007-02-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 379-88 Citation Subset: IM |
Affiliation:
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School of Physical and Health Education, Queen's University, Kingston, Ont., Canada K7L 3N6. luba16@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteries Carbon Dioxide / blood Estradiol / blood Female Follicular Phase / blood, physiology* Humans Ions / blood Luteal Phase / blood, physiology* Osmolar Concentration Partial Pressure Progesterone / blood Reference Values Respiratory Physiological Phenomena* |
| Chemical | |
Reg. No./Substance:
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0/Ions; 124-38-9/Carbon Dioxide; 50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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