Document Detail


Phasic menstrual cycle effects on the control of breathing in healthy women.
MedLine Citation:
PMID:  16542884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effects of menstrual cycle phase on ventilatory control. Fourteen eumenorrheic women were studied in the early follicular (FP; 1-6 days) and mid-luteal (LP; 20-24 days) phase of the menstrual cycle. Blood for the determination of arterial PCO(2) (PaCO(2)) , plasma strong ion difference ([SID]), progesterone ([P(4)]), and 17beta-estradiol ([E(2)]) concentrations were obtained at rest. Subjects performed a CO(2) rebreathing procedure that included prior hyperventilation and maintenance of iso-oxia to evaluate central and peripheral chemoreflex, and nonchemoreflex drives to breathe. Resting PaCO(2) and [SID] were lower; minute ventilation (V (E)), [P(4)] and [E(2)] were higher in the LP versus FP. Within the LP, significant correlations were observed for PaCO(2) with [P(4)], [E(2)] and [SID]. Menstrual cycle phase had no effect on the threshold or sensitivity of the central and/or peripheral ventilatory chemoreflex response to CO(2). Both (V (E)) and the ventilatory response to hypocapnia (representing nonchemoreflex drives to breathe) were approximately 1L/min greater in the LP versus FP accounting for the reduction in PaCO(2) . These data support the hypothesis that phasic menstrual cycle changes in PaCO(2) may be due, at least in part, to the stimulatory effects of [P(4)], [E(2)] and [SID] on ventilatory drive.
Authors:
Lubomira Slatkovska; Dennis Jensen; Gregory A L Davies; Larry A Wolfe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-15
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  154     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-02-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  379-88     Citation Subset:  IM    
Affiliation:
School of Physical and Health Education, Queen's University, Kingston, Ont., Canada K7L 3N6. luba16@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Arteries
Carbon Dioxide / blood
Estradiol / blood
Female
Follicular Phase / blood,  physiology*
Humans
Ions / blood
Luteal Phase / blood,  physiology*
Osmolar Concentration
Partial Pressure
Progesterone / blood
Reference Values
Respiratory Physiological Phenomena*
Chemical
Reg. No./Substance:
0/Ions; 124-38-9/Carbon Dioxide; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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