Document Detail


Phasic cutaneous input facilitates locomotor recovery after incomplete spinal injury in the chick.
MedLine Citation:
PMID:  7472337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Walking and swimming of hatchling chicks was videotaped before hemisection of the left thoracic cord and thereafter at regular intervals, for up to 2 wk. With the use of kinematic techniques, movements of the left knee and ankle were quantified to assess recovery of the ipsilateral leg during walking and swimming trials. To study the effects of exteroceptive (cutaneous) feedback in the absence of limb loading, one group of animals was also provided with cutaneous stimulation during swimming in the form of neutrally buoyant tubes that only contacted the foot during the retraction (extension) phase of the swim cycle. 2. One day after hemisection, for both swimming and walking, the left knee failed to extend normally, and the ankle joint remained hyperextended. During walking, all chicks adopted an asymmetric gait, whereas during swimming the left leg remained retracted and motionless. 3. Over the next 2 wk, knee extension and ankle flexion during walking recovered to normal preoperative values, but neither measure returned to preoperative values during swimming trials. However, when chicks were provided with phasic cutaneous stimulation during swimming trials, they showed improvements in leg motion as soon as 5 days after hemisection. Temporary removal of the cutaneous stimulation during swimming (5 days after hemisection) resulted in reduced limb action. However, 14 days after hemisection, the improvement in limb motion was retained even when the cutaneous stimulation was not provided. 4. Improvement in leg motion after swim training with phasic cutaneous stimulation took the form of increased extension of the limb during retraction. Possible neurophysiological mechanisms for this behavior include reflex reinforcement of limb extensor activity in response to cutaneous stimulation of the foot. Repeated exposure to phasic stimulation during swimming trials results in a permanent alteration in limb action. Thus increased cutaneous afferent inputs, even in the absence of limb loading, can facilitate locomotor recovery after spinal cord injury.
Authors:
G D Muir; J D Steeves
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  74     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-29     Completed Date:  1995-11-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  358-68     Citation Subset:  IM; S    
Affiliation:
Department of Zoology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chickens
Feedback / physiology
Joints / anatomy & histology,  physiology
Locomotion / physiology*
Physical Stimulation
Proprioception / physiology
Skin / innervation*
Skin Physiological Phenomena
Spinal Cord Injuries / physiopathology*
Swimming
Walking

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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