Document Detail


Phasic Changes in Cell Proliferation in an Autogenous Vein Graft used to Repair the Lacrimal Canaliculus in a Rabbit Model.
MedLine Citation:
PMID:  22399259     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There are few reports that describe the physiological changes in a vein graft used to reconstruct lacrimal canaliculus. This article aims to observe the phasic changes in cell proliferation in an autogenous vein graft used to repair the lacrimal canaliculus. Lacrimal canaliculus disjunction was made in a rabbit model by transecting one side of the lacrimal canaliculus. The injury was repaired using an autogenous ear vein graft. Phasic changes in cell proliferation were observed using reverse transcription polymerase chain reaction and immunohistochemistry for the expression of proliferating cell nuclear antigen in the grafted vein segment. At 3 days postoperative, cell proliferation in the grafted vein segment became active, peaking at 7 days postoperative. Cell proliferation became stable in the epithelium, but remained active in the subepithelial connective tissue at 28 days postoperative. The phasic changes in cell proliferation in the autogenous vein graft were consistent with a normal wound healing response.
Authors:
Zhigang Li; Yu Zhu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-7
Journal Detail:
Title:  Journal of reconstructive microsurgery     Volume:  -     ISSN:  1098-8947     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502670     Medline TA:  J Reconstr Microsurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
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