| Phase-variable surface structures are required for infection of Campylobacter jejuni by bacteriophages. | |
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MedLine Citation:
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PMID: 16820455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study characterizes the interaction between Campylobacter jejuni and the 16 phages used in the United Kingdom typing scheme by screening spontaneous mutants of the phage-type strains and transposon mutants of the sequenced strain NCTC 11168. We show that the 16 typing phages fall into four groups based on their patterns of activity against spontaneous mutants. Screens of transposon and defined mutants indicate that the phage-bacterium interaction for one of these groups appears to involve the capsular polysaccharide (CPS), while two of the other three groups consist of flagellatropic phages. The expression of CPS and flagella is potentially phase variable in C. jejuni, and the implications of these findings for typing and intervention strategies are discussed. |
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Authors:
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Chris Coward; Andrew J Grant; Craig Swift; Jennifer Philp; Rebecca Towler; Mohammad Heydarian; Jennifer A Frost; Duncan J Maskell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Applied and environmental microbiology Volume: 72 ISSN: 0099-2240 ISO Abbreviation: Appl. Environ. Microbiol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-05 Completed Date: 2006-09-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7605801 Medline TA: Appl Environ Microbiol Country: United States |
Other Details:
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Languages: eng Pagination: 4638-47 Citation Subset: IM |
Affiliation:
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Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Capsules / metabolism* Bacterial Typing Techniques Bacteriophage Typing* Bacteriophages / physiology* Campylobacter jejuni / classification, genetics, growth & development*, virology* DNA Transposable Elements Flagella / metabolism* Humans Lysogeny Mutation Phenotype |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Capsules; 0/DNA Transposable Elements |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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