Document Detail


Phase transition in the collective migration of tissue cells: experiment and model.
MedLine Citation:
PMID:  17280097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have recorded the swarming-like collective migration of a large number of keratocytes (tissue cells obtained from the scales of goldfish) using long-term videomicroscopy. By increasing the overall density of the migrating cells, we have been able to demonstrate experimentally a kinetic phase transition from a disordered into an ordered state. Near the critical density a complex picture emerges with interacting clusters of cells moving in groups. Motivated by these experiments we have constructed a flocking model that exhibits a continuous transition to the ordered phase, while assuming only short-range interactions and no explicit information about the knowledge of the directions of motion of neighbors. Placing cells in microfabricated arenas we found spectacular whirling behavior which we could also reproduce in simulations.
Authors:
B Szabó; G J Szöllösi; B Gönci; Zs Jurányi; D Selmeczi; Tamás Vicsek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-22
Journal Detail:
Title:  Physical review. E, Statistical, nonlinear, and soft matter physics     Volume:  74     ISSN:  1539-3755     ISO Abbreviation:  Phys Rev E Stat Nonlin Soft Matter Phys     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-06     Completed Date:  2007-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136452     Medline TA:  Phys Rev E Stat Nonlin Soft Matter Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  061908     Citation Subset:  IM    
Affiliation:
Department of Biological Physics, Eötvös University, Pázmány P. stny. 1A, H-1117 Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Aggregation / physiology*
Cell Communication / physiology*
Cells, Cultured
Computer Simulation
Goldfish / physiology*
Keratinocytes / cytology*,  physiology*
Models, Biological*
Phase Transition

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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