Document Detail

Phase I study of recombinant DNA granulocyte macrophage colony stimulating factor.
MedLine Citation:
PMID:  3071348     Owner:  NLM     Status:  MEDLINE    
In this Phase I study of rh GM-CSF three patients have been entered at each of the following dose levels--0.3, 1, 3, 10 and 30 micrograms/kg/day. The mean total white cell count (x 10(9)/l) over the first ten days of rh GM-CSF rose from 11 to 14 at 3 micrograms/kg, 8 to 23 at 10 micrograms/kg and 7 to 27 at 30 micrograms/kg. Side effects included transient pyrexias after the first two infusions of rh GM-CSF and bone pains which were severe and required analgesia in two patients receiving 30 micrograms/kg and one receiving 10 micrograms/kg. No neutralizing antibodies to rh GM-CSF have been detected in the six patients tested to date. Patients are now being studied at 60 micrograms/kg/day.
W P Steward; J H Scarffe; R Austin; D Crowther
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behring Institute Mitteilungen     Volume:  -     ISSN:  0301-0457     ISO Abbreviation:  Behring Inst. Mitt.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-04-26     Completed Date:  1989-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367532     Medline TA:  Behring Inst Mitt     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  324-6     Citation Subset:  IM    
CRC Department of Medical Oncology, Christie Hospital, Manchester, U.K.
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MeSH Terms
Colony-Stimulating Factors / therapeutic use,  toxicity*
Colorectal Neoplasms / drug therapy
Drug Evaluation
Granulocyte-Macrophage Colony-Stimulating Factor
Growth Substances / therapeutic use,  toxicity*
Leukocyte Count / drug effects
Neoplasms / drug therapy*
Neutrophils / cytology,  drug effects
Recombinant Proteins / therapeutic use,  toxicity*
Reg. No./Substance:
0/Colony-Stimulating Factors; 0/Growth Substances; 0/Recombinant Proteins; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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