| Phase I study of neocarzinostatin in children with cancer. | |
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MedLine Citation:
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PMID: 156067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-three children with advanced cancer refractory to conventional therapy received weekly iv doses of neocarzinostatin for 5 weeks. Doses were escalated from 500 to 6750 units/m2/week. Four types of toxic manifestations occurred: acute reactions consisting of shaking chills with or without fever and cyanosis (rigor), hypersensitivity, vomiting, and marrow depression. Evidence of oncolytic activity was limited to patients with acute leukemia in whom phase II trials at doses between 3000 and 4500 units/m2 appear warranted. |
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Authors:
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G Rivera; C Howarth; R J Aur; C B Pratt |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer treatment reports Volume: 62 ISSN: 0361-5960 ISO Abbreviation: Cancer Treat Rep Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-08-16 Completed Date: 1979-08-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607107 Medline TA: Cancer Treat Rep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2105-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibiotics, Antineoplastic / pharmacology* Bone Marrow / drug effects Child Child, Preschool Drug Evaluation Drug Hypersensitivity Humans Infant Leukemia, Lymphoid / drug therapy* Leukemia, Myeloid, Acute / drug therapy Neoplasms / drug therapy* Remission, Spontaneous Shivering / drug effects Vomiting / chemically induced Zinostatin / pharmacology*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 9014-02-2/Zinostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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