| Phase I study of intravenous fosquidone (GR63178A-NSC D611615) using a three times a week schedule. | |
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MedLine Citation:
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PMID: 1586634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a Phase I study fosquidone was administered to 23 patients (15 female, 8 male; mean age 53.6 years) with various solid tumours. Increasing doses (50-325 mg/m2) were given intravenously three times a week for 3 weeks. The MTD was established a 325 mg/m2 dose, the dose limiting factor being phlebitis in two of three patients. The other main side-effects were headache (9 patients), pain (11 patients) and nausea and vomiting (16 patients). The majority of these were mild (WHO grade 1-2), but two patients reported WHO grade 3 and 4 pain. There was no clear relationship between dose, severity and frequency of side-effects. Four tumour regressions (three minor and one partial response) were achieved at varying dose levels (50, 100, 160 and 325 mg/m2) in patients with different tumours (laryngeal, colorectal and lung). The recommended dose for Phase II studies is 250 mg/m2 given intravenously three times a week for 3 week. |
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Authors:
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A S Planting; M E van der Burg; G Stoter; P Beranek; J Verweij |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical oncology (Royal College of Radiologists (Great Britain)) Volume: 4 ISSN: 0936-6555 ISO Abbreviation: Clin Oncol (R Coll Radiol) Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-06-22 Completed Date: 1992-06-22 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9002902 Medline TA: Clin Oncol (R Coll Radiol) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 171-3 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents / administration & dosage, adverse effects, therapeutic use* Clinical Protocols Drug Administration Schedule Drug Evaluation Female Headache / chemically induced Humans Injections, Intravenous Isoquinolines / administration & dosage, adverse effects, therapeutic use* Male Middle Aged Nausea / chemically induced Neoplasms / drug therapy* Organophosphorus Compounds* Pain Phlebitis / chemically induced Remission Induction Vomiting / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Isoquinolines; 0/Organophosphorus Compounds; 114517-02-1/fosquidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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