Document Detail

Phase I/II study of high-dose rate interstitial radiotherapy for head and neck cancer.
MedLine Citation:
PMID:  1455289     Owner:  NLM     Status:  MEDLINE    
From July 1991 through December 1991, a phase I/II study of high-dose rate interstitial radiotherapy for head and neck cancer was performed to determine any acute adverse effects and mucosal reaction as well as the feasibility of this therapy. A total of seven patients with head and neck cancer (tongue: four cases; mouth floor: one case; buccal mucosa: one case; oral mucosa of lower lip: one case) were entered into this study. The dose schedule of high-dose rate interstitial radiotherapy ranged from 35 Gy/ten fractions (bid)/week to 60 Gy/ten fractions/week. No major or minor early complication was observed. Spotted mucositis appeared starting three days after the end of high-dose rate interstitial radiotherapy while confluent mucositis developed and approached a peak at ten days but disappeared by the fourth to eighth week. Early tumor responses of all patients were complete.
T Teshima; T Inoue; H Ikeda; S Murayama; S Furukawa; K Shimizutani
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]     Volume:  168     ISSN:  0179-7158     ISO Abbreviation:  Strahlenther Onkol     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8603469     Medline TA:  Strahlenther Onkol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  617-21     Citation Subset:  IM    
Department of Radiology, Osaka University Medical School, Japan.
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MeSH Terms
Aged, 80 and over
Brachytherapy / adverse effects*,  instrumentation
Head and Neck Neoplasms / radiotherapy*
Mouth Mucosa / radiation effects
Radiotherapy Dosage
Remission Induction
Time Factors

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