Document Detail

Phase-shifting effects of a serotonin agonist in tau mutant hamsters.
MedLine Citation:
PMID:  8883908     Owner:  NLM     Status:  MEDLINE    
Previous studies indicate that the advance region of the tau mutant hamster's phase-response curve (PRC) to non-photic stimuli, such as NPY and wheel pulses, is characterized by earlier timing and increased amplitude in comparison with that of wild-type animals. Since, recent evidence suggests that serotonergic pathways may play an important role for the non-photic phase resetting of the rodent circadian pacemaker, PRCs to the serotonin (5-HT) agonist, 8-OH-DPAT (5 mg/kg i.p), were generated in both wild-type and tau mutant hamsters kept in constant darkness. The results indicate that the tau mutation is associated with changes in the timing, but not the amplitude of the advance region of the PRC to 8-OH-DPAT and suggest that serotonergic agents and other non-photic or activity-inducing stimuli may share some common mechanisms for resetting the phase of the rodent circadian pacemaker.
E F Colecchia; P D Penev; P C Zee; F W Turek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  730     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-28     Completed Date:  1997-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  227-31     Citation Subset:  IM    
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA.
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MeSH Terms
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology*
Circadian Rhythm / drug effects*
Cricetinae / genetics*
Reference Values
Serotonin Agonists / pharmacology*
tau Proteins / genetics*
Grant Support
Reg. No./Substance:
0/Serotonin Agonists; 0/tau Proteins; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

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