Document Detail


Phase-shifting effects of light on the circadian rhythms of 5-methoxytryptophol and melatonin in the chick pineal gland.
MedLine Citation:
PMID:  10949534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the chick pineal gland, 5-methoxytryptophol and melatonin concentrations fluctuate in a rhythmic manner. These rhythms are circadian in nature persisting in constant darkness and have opposite phases. Acute exposure of chicks to white light (30 lux for 5, 10, 20, and 30 min) at night increased the amount of pineal 5-methoxytryptophol and decreased pineal melatonin content. A 6 hr pulse of light (100 lux) applied early in the subjective night (CT12-CT18) caused a delay in the phase of the circadian rhythms of 5-methoxytryptophol and melatonin by 3.7 and 4.5 h, respectively, compared to untreated controls. When the 6 hr light pulse was given during the late subjective night (C18 CT24) it advanced the phase of the 5-methoxytryptophol and melatonin rhythms by 8.1 and 11.9 h, respectively. In the chick pineal the phase-advancing effects of light on the circadian rhythms of 5-methoxytryptophol and melatonin were more pronounced than the phase-delaying effects. Our results provide the first evidence that light is capable of phase shifting the 5-methoxytryptophol rhythm in a manner similar to its action on the melatonin rhythm.
Authors:
J B Zawilska; B Vivien-Roels; D J Skene; P Pévet; J Z Nowak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pineal research     Volume:  29     ISSN:  0742-3098     ISO Abbreviation:  J. Pineal Res.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2000-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Biogenic Amines, Polish Academy of Sciences, Lódź. jerzyn@amina1.zabpan.lodz.pl
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MeSH Terms
Descriptor/Qualifier:
Animals
Chickens
Circadian Rhythm / radiation effects*
Indoles / metabolism*
Light
Male
Melatonin / metabolism*
Photoperiod
Pineal Gland / metabolism*,  radiation effects*
Chemical
Reg. No./Substance:
0/Indoles; 712-09-4/methoxytryptophol; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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