Document Detail

Phase resetting of the respiratory cycle before and after unilateral pontine lesion in cat.
MedLine Citation:
PMID:  1559953     Owner:  NLM     Status:  MEDLINE    
The pontine respiratory group (PRG) facilitates the mechanism for terminating the inspiratory phase but may influence other phases in the respiratory cycle as well. We determined the effects of PRG lesions on the response of the respiratory cycle to superior laryngeal nerve stimulation delivered in each phase of the cycle in decerebrate, vagotomized, paralyzed, and ventilated cats (n = 6). We measured the duration of inspiration (TI) and expiration (TE) for three breaths before and in the perturbed breath and TI for three breaths after the perturbation. The delay to next inspiration was plotted against the phase at which the stimulus was delivered. Before lesioning, premature inspiratory termination was followed by phase-dependent shortening of TE. After lesioning, premature inspiratory termination did not systematically change the following TE. Breath-by-breath variability (measured 50 breaths) increased and stimulus after-effects (prolonged TI in the subsequent cycle) were augmented following lesions. These data indicate that the PRG plays an important role in the control of TE after perturbation and in the stability of the respiratory central pattern generator.
Y Oku; T E Dick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  72     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-13     Completed Date:  1992-05-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  721-30     Citation Subset:  IM; S    
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
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MeSH Terms
Electric Stimulation
Laryngeal Nerves / physiology
Models, Biological
Phrenic Nerve / physiology
Pons / anatomy & histology,  physiology*
Respiratory Center / physiology*
Respiratory Mechanics / physiology*
Grant Support

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