| Phase-contrast MRI measurement of systolic cerebrospinal fluid peak velocity (CSFV(peak)) in the aqueduct of Sylvius: a noninvasive tool for measurement of cerebral capacity. | |
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MedLine Citation:
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PMID: 10360850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cerebrospinal fluid (CSF) outflow to intra- and extracranial subarachnoid spaces caused by arterial inflow to the brain predominantly compensates systolic increases in cerebral blood volume. Phase-contrast magnetic resonance imaging is a new tool for noninvasive assessment of CSF displacement by measuring CSF peak velocity (CSFV(Peak)). The authors tested this new tool in an experimental human model of increased intracranial pressure and reduced cerebral capacity by means of continuous positive airway pressure (CPAP) breathing. METHODS: The authors investigated systolic CSFV(Peak) in the aqueduct of Sylvius in 11 awake, normocapnic (end-tidal carbon dioxide [ET(CO2)] = 40 mmHg) volunteers without CPAP and at two different CPAP levels (6 and 12 cm H2O) by means of electroencephalography-gated phase-contrast magnetic resonance imaging. RESULTS: Administration of 6 cm H2O CPAP did not change systolic CSFV(Peak) (-4.9+/-2.8 cm/s vs. control: -5.1+/-2.7 cm/s), whereas 12 cm H2O CPAP significantly reduced systolic CSFV(Peak) (-4.0+/-1.8 cm/s vs. control: -5.1+/-2.7 cm/s; P < 0.05). CONCLUSIONS: These findings in awake volunteers show that monitoring CSFV(Peak) in the aqueduct of Sylvius is a sensitive method for detecting even minor impairment of cerebral capacity caused by experimentally induced increases in intracranial pressure. |
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Authors:
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C Kolbitsch; M Schocke; I H Lorenz; C Kremser; F Zschiegner; K P Pfeiffer; S Felber; F Aichner; C Hörmann; A Benzer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 90 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-06-17 Completed Date: 1999-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1546-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia and Intensive Care Medicine, The Leopold-Franzens University of Innsbruck, Austria. christian.kolbitsch@uibk.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Volume Cerebrospinal Fluid / physiology* Humans Intracranial Pressure* Magnetic Resonance Imaging Male Positive-Pressure Respiration Systole* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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