| Phase-contrast MRI-based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall. | |
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MedLine Citation:
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PMID: 19243040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique. MATERIALS AND METHODS: Female domestic pigs were randomized to a normal control group (N; n=5) or a renovascular hypertension group (HT; n=5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173+/-12 vs. 115+/-11 mmHg, P<or=0.05). The animals were euthanized after 3 months of hypertension and abdominal aortas harvested. The ex vivo aortic samples were then examined using a phase-contrast MRI-based elastography technique. RESULTS: The Young's modulus-wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571+/-0.080 vs. 0.419+/-0.026, P<0.05). Histological analysis and staining confirmed increased intima-media thickness and collagen content in the hypertensive aorta, while elastin staining showed no difference. CONCLUSION: The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension. |
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Authors:
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David A Woodrum; Joerg Herrmann; Amir Lerman; Anthony J Romano; Lilach O Lerman; Richard L Ehman |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 29 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-03 Completed Date: 2009-04-16 Revised Date: 2011-01-17 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 583-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Radiology Department, Mayo Clinic, Rochester, Minnesota 55905, USA. Woodrum.david@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Abdominal / pathology, ultrastructure Blood Pressure Body Weight Cholesterol / blood Disease Models, Animal Elasticity Imaging Techniques / methods* Female Hypertension / diagnosis* Magnetic Resonance Imaging / methods* Microscopy, Phase-Contrast Swine |
| Grant Support | |
ID/Acronym/Agency:
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DK73608/DK/NIDDK NIH HHS; EB001981/EB/NIBIB NIH HHS; R01 EB001981-08/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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