Document Detail


Phase behavior of bile acid/lipid/water systems containing model dietary lipids.
MedLine Citation:
PMID:  19682701     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary lipids are solubilized in bile acid micelles in the small intestine. In the present study, we investigate the phase behavior of bile acid/model rapeseed oil (or model beef tallow)/water systems to predict interfacial phenomena during consumption of a variety of foods. The structures of molecular assemblies are identified based on polarizing microscope images, wide-angle X-ray diffraction (WAXD) and small-angle X-ray scattering (SAXS). The results of in vitro tests suggest that an increase in the intake of model rapeseed oil causes the formation of multi-lamellar vesicles and lamellar liquid crystals. The molecules in the lamellar liquid crystal are formed highly ordered layer structure with the spacing of 8.8nm along the c-axis, while monoclinic packed structure is constructed as two-dimensional structure in ab-plane due to bulky molecular structures of bile acid and unsaturated fatty acid. When the model beef tallow composition in the model system is more than several wt.%, stearic acid crystals are extracted. Moreover, bicarbonate ions are important ingredients to solubilize >10wt.% of the model lipids. These phase transitions might be induced by the addition of dietary lipids in vivo during the consumption of oil or meat. Our findings are significant for understanding the lipid absorption process in the small intestine, and for developing medical and healthcare products.
Authors:
Yoshimune Nonomura; Keisuke Nakayama; Yuki Aoki; Atsuhiro Fujimori
Publication Detail:
Type:  Journal Article     Date:  2009-07-18
Journal Detail:
Title:  Journal of colloid and interface science     Volume:  339     ISSN:  1095-7103     ISO Abbreviation:  -     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-09-01     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043125     Medline TA:  J Colloid Interface Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-9     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Chemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa 992-8510, Japan. nonoy@yz.yamagata-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Bile Acids and Salts / chemistry*
Dietary Fats*
Glycerides / chemistry
Intestinal Absorption
Lipid Bilayers / chemistry
Lipids / chemistry*
Micelles
Microscopy, Polarization
Oleic Acid / chemistry
Phase Transition*
Plant Oils / chemistry
Scattering, Small Angle
Stearic Acids / chemistry
Water / chemistry*
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dietary Fats; 0/Glycerides; 0/Lipid Bilayers; 0/Lipids; 0/Micelles; 0/Plant Oils; 0/Stearic Acids; 112-80-1/Oleic Acid; 25496-72-4/monoolein; 57-11-4/stearic acid; 7732-18-5/Water; 8002-13-9/rapeseed oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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