| Phase behavior of bile acid/lipid/water systems containing model dietary lipids. | |
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MedLine Citation:
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PMID: 19682701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary lipids are solubilized in bile acid micelles in the small intestine. In the present study, we investigate the phase behavior of bile acid/model rapeseed oil (or model beef tallow)/water systems to predict interfacial phenomena during consumption of a variety of foods. The structures of molecular assemblies are identified based on polarizing microscope images, wide-angle X-ray diffraction (WAXD) and small-angle X-ray scattering (SAXS). The results of in vitro tests suggest that an increase in the intake of model rapeseed oil causes the formation of multi-lamellar vesicles and lamellar liquid crystals. The molecules in the lamellar liquid crystal are formed highly ordered layer structure with the spacing of 8.8nm along the c-axis, while monoclinic packed structure is constructed as two-dimensional structure in ab-plane due to bulky molecular structures of bile acid and unsaturated fatty acid. When the model beef tallow composition in the model system is more than several wt.%, stearic acid crystals are extracted. Moreover, bicarbonate ions are important ingredients to solubilize >10wt.% of the model lipids. These phase transitions might be induced by the addition of dietary lipids in vivo during the consumption of oil or meat. Our findings are significant for understanding the lipid absorption process in the small intestine, and for developing medical and healthcare products. |
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Authors:
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Yoshimune Nonomura; Keisuke Nakayama; Yuki Aoki; Atsuhiro Fujimori |
Publication Detail:
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Type: Journal Article Date: 2009-07-18 |
Journal Detail:
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Title: Journal of colloid and interface science Volume: 339 ISSN: 1095-7103 ISO Abbreviation: - Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-09-01 Completed Date: 2009-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043125 Medline TA: J Colloid Interface Sci Country: United States |
Other Details:
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Languages: eng Pagination: 222-9 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Chemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa 992-8510, Japan. nonoy@yz.yamagata-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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chemistry* Dietary Fats* Glycerides / chemistry Intestinal Absorption Lipid Bilayers / chemistry Lipids / chemistry* Micelles Microscopy, Polarization Oleic Acid / chemistry Phase Transition* Plant Oils / chemistry Scattering, Small Angle Stearic Acids / chemistry Water / chemistry* X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Dietary Fats; 0/Glycerides; 0/Lipid Bilayers; 0/Lipids; 0/Micelles; 0/Plant Oils; 0/Stearic Acids; 112-80-1/Oleic Acid; 25496-72-4/monoolein; 57-11-4/stearic acid; 7732-18-5/Water; 8002-13-9/rapeseed oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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