Document Detail

Phase-based arterial input function measurements for dynamic susceptibility contrast MRI.
MedLine Citation:
PMID:  20665779     Owner:  NLM     Status:  MEDLINE    
In dynamic susceptibility contrast perfusion MRI, arterial input function (AIF) measurements using the phase of the MR signal are traditionally performed inside an artery. However, phase-based AIF selection is also feasible in tissue surrounding an artery such as the middle cerebral artery, which runs approximately perpendicular to B(0) since contrast agents also induce local field changes in tissue surrounding the artery. The aim of this study was to investigate whether phase-based AIF selection is better performed in tissue just outside the middle cerebral artery than inside the artery. Additionally, phase-based AIF selection was compared to magnitude-based AIF selection. Both issues were studied theoretically and using numerical simulations, producing results that were validated using phantom experiments. Finally, an in vivo experiment was performed to illustrate the feasibility of phase-based AIF selection. Three main findings are presented: first, phase-based AIF selections are better made in tissue outside the middle cerebral artery, rather than within the middle cerebral artery, since in the latter approach partial-volume effects affect the shape of the estimated AIF. Second, optimal locations for phase-based AIF selection are similar for different clinical dynamic susceptibility contrast MRI sequences. Third, phase-based AIF selection allows more locations in tissue to be chosen that show the correct AIF than does magnitude-based AIF selection.
Egbert J W Bleeker; Mark A van Buchem; Andrew G Webb; Matthias J P van Osch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  64     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-68     Citation Subset:  IM    
C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Brain / pathology*
Contrast Media
Gadolinium DTPA / diagnostic use*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Intracranial Arteriovenous Malformations / pathology*
Pattern Recognition, Automated / methods*
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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