| Phase assemblage study and cytocompatibility property of heat treated potassium magnesium phosphate-silicate ceramics. | |
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MedLine Citation:
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PMID: 19301102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article reports the study on a new generation bioactive ceramic, based on MgKPO(4) (Magnesium Potassium Phosphate, abbreviated as MKP) for biomedical applications. A series of heat treatment experiments on the slip cast silica (SiO(2)) containing MKP ceramics were carried out at 900, 1,000 and 1,100 degrees C for 4 h in air. The density of the slip cast ceramic increases to 2.5 gm/cm(3) upon heat treatment at 900 degrees C. However, no significant change in density is measured upon heat treatment to higher temperature of 1,000 and 1,100 degrees C. On the basis of XRD results, the presence of K(2)MgSi(5)O(12) and dehydrated MgKPO(4) were confirmed and complementary information has also been obtained using FT-IR and Raman spectroscopy. In order to confirm the in vitro cytocompatibility property, the cell culture tests were carried out on selected samples and the results reveal good cell adhesion and spreading of L929 mouse fibroblast cells. MTT assay analysis with L929 cells confirmed non-cytotoxic behavior of MKP containing ceramics and the results are comparable with sintered HAp ceramics. It is expected that the newly developed MKP based materials could be a good substitute for hydroxyapatite (HAp or HA) based bioceramics. |
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Authors:
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Ravi Kumar; Sushma Kalmodia; Shekhar Nath; Dileep Singh; Bikramjit Basu |
Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2009-03-20 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 20 ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-17 Completed Date: 2009-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 1689-95 Citation Subset: IM |
Affiliation:
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Laboratory for Advanced Ceramics, Department Materials and Metallurgical Engineering, Indian Institute of Technology Kanpur, Kanpur, UP, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion / physiology Cell Survival / physiology Cells, Cultured Ceramics / chemical synthesis*, chemistry, pharmacology Fibroblasts / physiology Hot Temperature* Magnesium Compounds / chemistry* Materials Testing Mice Phase Transition Phosphates / chemistry* Potassium Compounds / chemistry* Silicates / chemical synthesis*, chemistry, pharmacology Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Ceramics; 0/Magnesium Compounds; 0/Phosphates; 0/Potassium Compounds; 0/Silicates; 10043-83-1/magnesium phosphate; 16068-46-5/potassium phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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