Document Detail

Phase assemblage study and cytocompatibility property of heat treated potassium magnesium phosphate-silicate ceramics.
MedLine Citation:
PMID:  19301102     Owner:  NLM     Status:  MEDLINE    
This article reports the study on a new generation bioactive ceramic, based on MgKPO(4) (Magnesium Potassium Phosphate, abbreviated as MKP) for biomedical applications. A series of heat treatment experiments on the slip cast silica (SiO(2)) containing MKP ceramics were carried out at 900, 1,000 and 1,100 degrees C for 4 h in air. The density of the slip cast ceramic increases to 2.5 gm/cm(3) upon heat treatment at 900 degrees C. However, no significant change in density is measured upon heat treatment to higher temperature of 1,000 and 1,100 degrees C. On the basis of XRD results, the presence of K(2)MgSi(5)O(12) and dehydrated MgKPO(4) were confirmed and complementary information has also been obtained using FT-IR and Raman spectroscopy. In order to confirm the in vitro cytocompatibility property, the cell culture tests were carried out on selected samples and the results reveal good cell adhesion and spreading of L929 mouse fibroblast cells. MTT assay analysis with L929 cells confirmed non-cytotoxic behavior of MKP containing ceramics and the results are comparable with sintered HAp ceramics. It is expected that the newly developed MKP based materials could be a good substitute for hydroxyapatite (HAp or HA) based bioceramics.
Ravi Kumar; Sushma Kalmodia; Shekhar Nath; Dileep Singh; Bikramjit Basu
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-03-20
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  20     ISSN:  1573-4838     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-17     Completed Date:  2009-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1689-95     Citation Subset:  IM    
Laboratory for Advanced Ceramics, Department Materials and Metallurgical Engineering, Indian Institute of Technology Kanpur, Kanpur, UP, India.
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MeSH Terms
Cell Adhesion / physiology
Cell Survival / physiology
Cells, Cultured
Ceramics / chemical synthesis*,  chemistry,  pharmacology
Fibroblasts / physiology
Hot Temperature*
Magnesium Compounds / chemistry*
Materials Testing
Phase Transition
Phosphates / chemistry*
Potassium Compounds / chemistry*
Silicates / chemical synthesis*,  chemistry,  pharmacology
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
X-Ray Diffraction
Reg. No./Substance:
0/Ceramics; 0/Magnesium Compounds; 0/Phosphates; 0/Potassium Compounds; 0/Silicates; 10043-83-1/magnesium phosphate; 16068-46-5/potassium phosphate

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