| Phase I Study of Combination Chemotherapy Consisting of Paclitaxel, Cisplatin, and S-1 in Patients with Unresectable Gastric Cancer (KOGC-02). | |
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MedLine Citation:
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PMID: 23225443 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Triplet combination chemotherapy has the potential to improve the prognosis of patients with unresectable gastric cancer. We conducted a phase I trial of triplet combination chemotherapy consisting of paclitaxel, cisplatin, and S-1 (PCS) for unresectable gastric cancer. PATIENTS AND METHODS: Patients with metastatic or incurable disease were enrolled. S-1 was administered on days 1-14. Paclitaxel and cisplatin were infused on days 1 and 15. The starting doses of paclitaxel and cisplatin were 100 and 20 mg/m(2), respectively. Dose levels of paclitaxel and cisplatin were escalated as follows: 120 and 20 mg/m(2), respectively (level 2); 120 and 30 mg/m(2), respectively (level 3). End-points: Dose-limiting toxicities included grade 3 nausea, vomiting, and general fatigue, and grade 4 febrile neutropenia. The maximum tolerated dose and recommended dose were established at level 3 and level 2, respectively. CONCLUSION: Although further clinical trials are recommended to more thoroughly evaluate safety and efficacy, PCS appears to be an excellent candidate for a standard treatment strategy for unresectable gastric cancer. |
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Authors:
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Tsunehiro Takahashi; Yoshiro Saikawa; Kazumasa Fukuda; Shinsuke Funakoshi; Hirofumi Kawakubo; Hiroya Takeuchi; Hiromasa Takaishi; Yuko Kitagawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 5401-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 Japan. saiky@z8.keio.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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