| Phase misalignment between suprachiasmatic neuronal oscillators impairs photic behavioral phase shifts but not photic induction of gene expression. | |
| | |
MedLine Citation:
|
PMID: 20881133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The ability of the circadian pacemaker within the suprachiasmatic nucleus (SCN) to respond to light stimulation in a phase-specific manner constitutes the basis for photic entrainment of circadian rhythms. The neural basis for this phase specificity is unclear. We asked whether a lack of synchrony between SCN neurons, as reflected in phase misalignment between dorsomedial (dmSCN) and ventrolateral (vlSCN) neuronal oscillators in the rat, would impact the ability of the pacemaker to respond to phase-resetting light pulses. Light pulses delivered at maximal phase misalignment between the vlSCN and dmSCN oscillators increased expression of Per1 mRNA, regardless of the circadian phase of the dmSCN. However, phase shifts of locomotor activity were only observed when the vlSCN and dmSCN were phase aligned at the time of stimulation. Our results fit a model in which a vlSCN oscillator phase gates its own response to light and in turn relays light information to a dmSCN oscillator. This model predicts that the phase misalignment that results from circadian internal desynchronization could preserve the ability of light to induce gene expression within the master circadian clock but impair its ability to induce behavioral phase shifts. |
| | |
Authors:
|
Michael D Schwartz; Seth Congdon; Horacio O de la Iglesia |
Related Documents
:
|
11302553 - Assembling a clock for all seasons: are there m and e oscillators in the genes? 22457733 - Advantage of hole stimulus in rivalry competition. 20498483 - A biomechanical assessment of isometric handgrip force and fatigue at different anatomi... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-30 Completed Date: 2010-10-25 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 13150-6 Citation Subset: IM |
Affiliation:
|
Department of Biology and Program of Neurobiology and Behavior, University of Washington, Seattle, Washington 98195, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Animal / physiology, radiation effects Biological Clocks / genetics*, radiation effects Circadian Rhythm / genetics*, radiation effects Gene Expression Regulation / radiation effects Light* Male Motor Activity / genetics, radiation effects Neural Pathways / cytology, metabolism, radiation effects Neurons / metabolism*, radiation effects Photic Stimulation / methods* Rats Rats, Wistar Suprachiasmatic Nucleus / cytology, metabolism*, radiation effects |
| Grant Support | |
ID/Acronym/Agency:
|
R01 MH075016-04/MH/NIMH NIH HHS; R01MH075016/MH/NIMH NIH HHS |
| Comments/Corrections | |
Erratum In:
|
J Neurosci. 2010 Oct 20;30(42):14284 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of T...
Next Document: Manipulation of adenosine kinase affects sleep regulation in mice.