| Phase-locked responses to tones of chinchilla auditory nerve fibers: implications for apical cochlear mechanics. | |
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MedLine Citation:
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PMID: 19921334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Responses to tones with frequency < or = 5 kHz were recorded from auditory nerve fibers (ANFs) of anesthetized chinchillas. With increasing stimulus level, discharge rate-frequency functions shift toward higher and lower frequencies, respectively, for ANFs with characteristic frequencies (CFs) lower and higher than approximately 0.9 kHz. With increasing frequency separation from CF, rate-level functions are less steep and/or saturate at lower rates than at CF, indicating a CF-specific nonlinearity. The strength of phase locking has lower high-frequency cutoffs for CFs >4 kHz than for CFs < 3 kHz. Phase-frequency functions of ANFs with CFs lower and higher than approximately 0.9 kHz have inflections, respectively, at frequencies higher and lower than CF. For CFs >2 kHz, the inflections coincide with the tip-tail transitions of threshold tuning curves. ANF responses to CF tones exhibit cumulative phase lags of 1.5 periods for CFs 0.7-3 kHz and lesser amounts for lower CFs. With increases of stimulus level, responses increasingly lag (lead) lower-level responses at frequencies lower (higher) than CF, so that group delays are maximal at, or slightly above, CF. The CF-specific magnitude and phase nonlinearities of ANFs with CFs < 2.5 kHz span their entire response bandwidths. Several properties of ANFs undergo sharp transitions in the cochlear region with CFs 2-5 kHz. Overall, the responses of chinchilla ANFs resemble those in other mammalian species but contrast with available measurements of apical cochlear vibrations in chinchilla, implying that either the latter are flawed or that a nonlinear "second filter" is interposed between vibrations and ANF excitation. |
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Authors:
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Andrei N Temchin; Mario A Ruggero |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-11-17 |
Journal Detail:
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Title: Journal of the Association for Research in Otolaryngology : JARO Volume: 11 ISSN: 1438-7573 ISO Abbreviation: J. Assoc. Res. Otolaryngol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-07-23 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 100892857 Medline TA: J Assoc Res Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 297-318 Citation Subset: IM |
Affiliation:
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Hugh Knowles Center (Department of Communication Sciences and Disorders), Northwestern University, 2240 Campus Drive, Evanston, IL 60208-3550, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Anesthesia Animals Auditory Threshold / physiology Chinchilla Cochlea / cytology*, physiology* Cochlear Nerve / cytology*, physiology* Electrophysiology Nerve Fibers / physiology* Noise Species Specificity Vibration |
| Grant Support | |
ID/Acronym/Agency:
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DC-000419/DC/NIDCD NIH HHS; R01 DC000419-19/DC/NIDCD NIH HHS; R01 DC000419-21/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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