Document Detail


Phase II trial of cisplatin and tegafur (Ftorafur) as initial therapy in squamous-cell carcinoma of the head and neck.
MedLine Citation:
PMID:  2116085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cisplatin and 5-fluorouracil infusion combination produces a high response rate in squamous-cell carcinoma of the head and neck. Tegafur (Ftorafur) is an analog of 5-fluorouracil, and its oral form is well absorbed. This agent has a moderate toxicity. We report a study to determine the efficacy of the cisplatin (100 mg/m2, day 1) and tegafur (1,000 mg/m2 daily for 21 days) combination. Thirty-nine patients entered the study; 36 were evaluable for response. Overall response was 94%, with a 22% complete response. Toxicity was moderate. We conclude that the cisplatin and tegafur combination is active in untreated patients with head and neck cancer.
Authors:
M Gonzalez-Baron; J Vicente; M Tomas; G Martin; V Martorell; C Garcia-Giron; P Garrido; J Gavilan; P Zamora
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  13     ISSN:  0277-3732     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-06     Completed Date:  1990-09-06     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, Hospital La Paz, Facultad de Medicina, Universidad Autonoma, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*,  toxicity
Carcinoma, Squamous Cell / drug therapy*
Cisplatin / administration & dosage*,  toxicity
Drug Evaluation
Female
Head and Neck Neoplasms / drug therapy*
Humans
Injections, Intravenous
Male
Middle Aged
Remission Induction
Tegafur / administration & dosage*,  toxicity
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin; 17902-23-7/Tegafur

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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