| Phase II study of nimustine hydrochloride (ACNU) plus paclitaxel for refractory small cell lung cancer. | |
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MedLine Citation:
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PMID: 19342118 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: Bi-weekly administrations of nimustine hydrochloride (ACNU) plus paclitaxel were evaluated in this phase II study in patients with refractory small cell lung cancer (SCLC). METHODS: Patients who had disease progression within 3 months after treatment with irinotecan (CPT-11)-containing regimens were entered. They were treated with every other week administrations of ACNU 50 mg/m(2) plus paclitaxel 110 mg/m(2) on day 1 over 2 weeks. RESULTS: Twenty-four patients (20 males and 4 females, median age of 64 years, 17 patients with Eastern Cooperative Oncology Group [ECOG] performance status [PS] 0-1 and 7 patients with PS 2) participated in the trial. Of the 24 refractory patients after CPT-11 containing regimens, 17 patients had been given etoposide plus platinum. There were six partial responses, and an overall response rate of 25% (95% confidence interval, 10-46%) was obtained. The median time to progression and the median survival time after enrollment into this study were 2.8 and 5.8 months, respectively. The median overall survival from the first-line treatment was 19.5 months. The major toxicity was myelosuppression. Grade 4 neutropenia occurred in 13% of patients, and Grade 4 thrombocytopenia was observed in 13% of patients. There was one treatment-related death, attributed to pneumonitis. CONCLUSION: Bi-weekly administrations of ACNU plus paclitaxel provided a practical and well-tolerated regimen that was active for CPT-11-refractory SCLC. |
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Authors:
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Kazutoshi Isobe; Kunihiko Kobayashi; Seiji Kosaihira; Futoshi Kurimoto; Hiroshi Sakai; Yuka Uchida; Yoshiaki Nagai; Takefumi Yamaguchi; Akihiko Miyanaga; Makoto Ando; Gaku Mori; Mitsunori Hino; Akihiko Gemma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-01 |
Journal Detail:
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Title: Lung cancer (Amsterdam, Netherlands) Volume: 66 ISSN: 1872-8332 ISO Abbreviation: Lung Cancer Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800805 Medline TA: Lung Cancer Country: Ireland |
Other Details:
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Languages: eng Pagination: 350-4 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Toho University Omori Medical Center, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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