| Phase II Study on Voriconazole for Treatment of Chinese Patients with Malignant Hematological Disorders and Invasive Aspergillosis. | |
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MedLine Citation:
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PMID: 22901231 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To investigate the efficacy and safety of voriconazole in treating Chinese patients with hematological malignancies and invasive aspergillosis. Methods: From March 2007 to April 2012, patients with diagnoses confirmed by CT, GM test and/or PCR assays, were recruited into this study. Aspergillosis of all patients were treated with voriconazole 6 mg/kg intravenous infusion (iv) every 12 h for 1 day, followed by 4 mg/kg IV every 12 h for 10-15 days; Then, switch to oral administration that was 200mg every 12h for 4-12 weeks. Efficacy and safety were evaluated according to Practice Guideline of Infectious Diseases Society of America. Results: The overall response rate of 38 patients after voriconazole treatment was 81.6%. The median time to pyretolysis was 4.5 days. Treatment related side effects were mild and found in only 15.8% of cases. No treatment related deaths occurred. Conclusions: Voriconazole can considered to be a safe and effective front-line therapy to treat patients with hematological malignancies and invasive aspergillosis. Alternatively it could be used as a remedial treatment when other antifungal therapies are ineffective. |
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Authors:
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Xue-Zhong Zhang; Xin-En Huang; Yan-Li Xu; Xiu-Qun Zhang; Ai-Ling Su; Zheng-Shan Shen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of cancer prevention : APJCP Volume: 13 ISSN: 1513-7368 ISO Abbreviation: Asian Pac. J. Cancer Prev. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-08-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130625 Medline TA: Asian Pac J Cancer Prev Country: Thailand |
Other Details:
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Languages: eng Pagination: 2415-8 Citation Subset: IM |
Affiliation:
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Hematology Department of Nanjing First Hospital, Nanjing Medical University, Nanjing, China E-mail : huangxinen06@yahoo.com.cn, shen630406@sohu.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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