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Phase II Study of Preoperative Chemoradiation with S-1 plus Oxaliplatin in Patients with Locally Advanced Rectal Cancer.
MedLine Citation:
PMID:  23057495     Owner:  NLM     Status:  Publisher    
We conducted a phase II study of preoperative chemoradiation (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer. The total radiotherapy dose was 50.4 Gy. Chemotherapy consisted of oxaliplatin 50 mg/m(2) on day 1, 8, 22 and 29, and S-1 80 mg/m(2) /day on day 1-14 and 22-35. Tumor apparent diffusion coefficient (ADC) was measured by diffusion weighted magnetic resonance imaging (DW-MRI) before and after CRT. Total mesorectal excision was performed within 6±2 weeks. The primary endpoint was pathologic complete response (pCR) rate. A total of 38 patients were enrolled. The pCR rate was 22.9% (8/35, 95% CI, 10.9-42.1), and ten patients (28.6%) showed near-total tumor regression. There was no grade 4 adverse event, and grade 3 adverse events included leukopenia (5.4%), diarrhea (5.4%), anorexia (2.7%), and nausea (2.7%). Tumor ADCs were calculated in 38 patients (including those who participated in the phase I study). The post-CRT ADC (p=0.037) and the percentage change in ADC (p=0.026) were significantly correlated with pathologic response. In conclusion, preoperative CRT with S-1 plus oxaliplatin showed promising results in pathologic responses and favorable toxicity profiles.
Eun Mi Lee; Yong Sang Hong; Kyu-Pyo Kim; Jae-Lyun Lee; Sun Young Kim; Young Suk Park; Doo Ho Choi; Jong Hoon Kim; Seok-Byung Lim; Chang Sik Yu; Jin Cheon Kim; Ju Hee Lee; Ah Young Kim; Tae Won Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Japanese Cancer Association.
Department of Oncology, University of Ulsan College of Medicine, Seoul.
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