| Phase II Study of Preoperative Chemoradiation with S-1 plus Oxaliplatin in Patients with Locally Advanced Rectal Cancer. | |
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MedLine Citation:
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PMID: 23057495 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We conducted a phase II study of preoperative chemoradiation (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer. The total radiotherapy dose was 50.4 Gy. Chemotherapy consisted of oxaliplatin 50 mg/m(2) on day 1, 8, 22 and 29, and S-1 80 mg/m(2) /day on day 1-14 and 22-35. Tumor apparent diffusion coefficient (ADC) was measured by diffusion weighted magnetic resonance imaging (DW-MRI) before and after CRT. Total mesorectal excision was performed within 6±2 weeks. The primary endpoint was pathologic complete response (pCR) rate. A total of 38 patients were enrolled. The pCR rate was 22.9% (8/35, 95% CI, 10.9-42.1), and ten patients (28.6%) showed near-total tumor regression. There was no grade 4 adverse event, and grade 3 adverse events included leukopenia (5.4%), diarrhea (5.4%), anorexia (2.7%), and nausea (2.7%). Tumor ADCs were calculated in 38 patients (including those who participated in the phase I study). The post-CRT ADC (p=0.037) and the percentage change in ADC (p=0.026) were significantly correlated with pathologic response. In conclusion, preoperative CRT with S-1 plus oxaliplatin showed promising results in pathologic responses and favorable toxicity profiles. |
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Authors:
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Eun Mi Lee; Yong Sang Hong; Kyu-Pyo Kim; Jae-Lyun Lee; Sun Young Kim; Young Suk Park; Doo Ho Choi; Jong Hoon Kim; Seok-Byung Lim; Chang Sik Yu; Jin Cheon Kim; Ju Hee Lee; Ah Young Kim; Tae Won Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
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Title: Cancer science Volume: - ISSN: 1349-7006 ISO Abbreviation: Cancer Sci. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Japanese Cancer Association. |
Affiliation:
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Department of Oncology, University of Ulsan College of Medicine, Seoul. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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