Document Detail


A phase II, randomized, controlled trial of acupuncture for reduction of Postcolectomy Ileus.
MedLine Citation:
PMID:  23188543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Postoperative ileus (POI) prolongs hospital stay and increases risk of postoperative complications. We conducted a randomized, sham-controlled trial to evaluate whether acupuncture reduces POI more effectively than sham acupuncture.
METHODS: Colon cancer patients undergoing elective colectomy were randomized to receive 30 min of true or sham acupuncture twice daily during their first 3 postoperative days. GI-3 (the later of the following two events: time that the patient first tolerated solid food, AND time that the patient first passed flatus OR a bowel movement) and GI-2 (the later of the following two events: time patient first tolerated solid food AND time patient first passed a bowel movement) were determined. Pain, nausea, vomiting, and use of pain medications were evaluated daily for the first 3 postoperative days.
RESULTS: Ninety patients were randomized. Eighty-one received the allocated intervention: 39 in the true acupuncture group and 42 in the sham acupuncture group, all evaluated for the primary endpoint. The mean time to GI-3 was 149 h [standard deviation (SD) 71 h] and 146 (SD 62 h) after surgery for the acupuncture group and the sham acupuncture group (difference between means -2 h; 95 % confidence interval -31, 26; p = 0.9). No significant differences were found between groups for secondary endpoints.
CONCLUSIONS: True acupuncture as provided in this study did not reduce POI more significantly than sham acupuncture. The study was limited by a standard deviation much larger than expected, suggesting that a study with a larger sample size might be required.
Authors:
Gary Deng; W Douglas Wong; Jose Guillem; Yi Chan; Theresa Affuso; K Simon Yeung; Marci Coleton; Daniel Sjoberg; Andrew Vickers; Barrie Cassileth
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Publication Detail:
Type:  Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-11-28
Journal Detail:
Title:  Annals of surgical oncology     Volume:  20     ISSN:  1534-4681     ISO Abbreviation:  Ann. Surg. Oncol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-10     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  9420840     Medline TA:  Ann Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1164-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acupuncture*
Colectomy / adverse effects*
Colonic Neoplasms / surgery
Female
Follow-Up Studies
Humans
Ileus / etiology,  prevention & control*
Intervention Studies
Length of Stay
Male
Middle Aged
Neoplasm Staging
Postoperative Complications*
Prognosis
Prospective Studies
Survival Rate
Grant Support
ID/Acronym/Agency:
P30 CA008748/CA/NCI NIH HHS; R21 CA122199/CA/NCI NIH HHS; R21CA122199/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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