|A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.|
|PMID: 22634319 Owner: NLM Status: MEDLINE|
|PURPOSE: Bardoxolone methyl, a novel synthetic triterpenoid and antioxidant inflammation modulator, potently induces Nrf2 and inhibits NF-κB and Janus-activated kinase/STAT signaling. This first-in-human phase I clinical trial aimed to determine the dose-limiting toxicities (DLT), maximum tolerated dose (MTD), and appropriate dose for phase II studies; characterize pharmacokinetic and pharmacodynamic parameters; and assess antitumor activity.
EXPERIMENTAL DESIGN: Bardoxolone methyl was administered orally once daily for 21 days of a 28-day cycle. An accelerated titration design was employed until a grade 2-related adverse event occurred. A standard 3 + 3 dose escalation was then employed until the MTD was reached. Single dose and steady-state plasma pharmacokinetics of the drug were characterized. Assessment of Nrf2 activation was examined in peripheral blood mononuclear cells (PBMC) by measuring NAD(P)H:quinone oxidoreductase (NQO1) mRNA levels. Immunohistochemical assessment of markers of inflammation, cell cycle, and apoptosis was carried out on tumor biopsies.
RESULTS: The DLTs were grade 3 reversible liver transaminase elevations. The MTD was established as 900 mg/d. A complete tumor response occurred in a mantle cell lymphoma patient, and a partial response was observed in an anaplastic thyroid carcinoma patient. NQO1 mRNA levels increased in PBMCs, and NF-κB and cyclin D1 levels decreased in tumor biopsies. Estimated glomerular filtration rate (eGFR) was also increased.
CONCLUSIONS: Bardoxolone methyl was well tolerated with an MTD of 900 mg/d. The increase in eGFR suggests that bardoxolone methyl might be beneficial in chronic kidney disease. Objective tumor responses and pharmacodynamic effects were observed, supporting continued development of other synthetic triterpenoids in cancer.
|David S Hong; Razelle Kurzrock; Jeffrey G Supko; Xiaoying He; Aung Naing; Jennifer Wheler; Donald Lawrence; Joseph Paul Eder; Colin J Meyer; Deborah A Ferguson; James Mier; Marina Konopleva; Sergej Konoplev; Michael Andreeff; Donald Kufe; Hillard Lazarus; Geoffrey I Shapiro; Bruce J Dezube|
Related Documents :
|343209 - Therapeutic responses of piglets to experimentally induced colibacillosis.
6784129 - Metabolism of sulfadiazine in children with protein calorie malnutrition.
17697219 - The effect of dilution and prolonged injection time on fentanyl-induced coughing.
25039609 - Evening dosing of antihypertensive therapy to reduce cardiovascular events: a third typ...
23097669 - Practical approaches to the use of lenalidomide in multiple myeloma: a canadian consensus.
18456459 - Effects of garlic on the induction of ventricular fibrillation.
7904269 - Interleukin-1 receptor antagonist ameliorates experimental anti-glomerular basement mem...
17351379 - Blood pressure lowering after experimental cerebral ischemia provides neurovascular pro...
25320049 - Complex disposition of methylthioninium redox forms determines efficacy in tau aggregat...
|Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-05-25|
|Title: Clinical cancer research : an official journal of the American Association for Cancer Research Volume: 18 ISSN: 1078-0432 ISO Abbreviation: Clin. Cancer Res. Publication Date: 2012 Jun|
|Created Date: 2012-06-18 Completed Date: 2012-12-20 Revised Date: 2014-09-24|
Medline Journal Info:
|Nlm Unique ID: 9502500 Medline TA: Clin Cancer Res Country: United States|
|Languages: eng Pagination: 3396-406 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Antineoplastic Agents / adverse effects, pharmacokinetics, therapeutic use*
Carcinoma, Renal Cell / drug therapy
Colorectal Neoplasms / drug therapy
Cyclin D1 / metabolism
Dose-Response Relationship, Drug
Drug Administration Schedule
Janus Kinases / antagonists & inhibitors
Kidney Neoplasms / drug therapy
Lymphoma / drug therapy*
Maximum Tolerated Dose
Melanoma / drug therapy
NAD(P)H Dehydrogenase (Quinone) / genetics, metabolism
NF-E2-Related Factor 2 / metabolism
NF-kappa B / metabolism
Neoplasms / drug therapy*
Oleanolic Acid / adverse effects, analogs & derivatives*, pharmacokinetics, therapeutic use
RNA, Messenger / genetics, metabolism
STAT Transcription Factors / antagonists & inhibitors
Thyroid Neoplasms / drug therapy
|P30 CA016672/CA/NCI NIH HHS|
|0/Antineoplastic Agents; 0/NF-E2-Related Factor 2; 0/NF-kappa B; 0/NFE2L2 protein, human; 0/RNA, Messenger; 0/STAT Transcription Factors; 0/methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate; 136601-57-5/Cyclin D1; 6SMK8R7TGJ/Oleanolic Acid; EC 220.127.116.11/NAD(P)H Dehydrogenase (Quinone); EC 18.104.22.168/NQO1 protein, human; EC 22.214.171.124/Janus Kinases|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exploring the effect of different plant lignin content and composition on ionic liquid pretreatment ...
Next Document: Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animal...