Document Detail


Phase behaviour and formation of fatty acid esters nanoemulsions containing piroxicam.
MedLine Citation:
PMID:  23386307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acid esters are long-chain esters, produced from the reaction of fatty acids and alcohols. They possess potential applications in cosmetic and pharmaceutical formulations due to their excellent wetting behaviour at interfaces and a non-greasy feeling when applied on the skin surfaces. This preliminary work was carried out to construct pseudo-ternary phase diagrams for oleyl laurate, oleyl stearate and oleyl oleate with surfactants and piroxicam. Then, the preparation and optimization study via 'One-At-A-Time Approach' were carried out to determine the optimum amount of oil, surfactants and stabilizer using low-energy emulsification method. The results revealed that multi-phase region dominated the three pseudo-ternary phase diagrams. A composition was chosen from each multi-phase region for preparing the nanoemulsions systems containing piroxicam by incorporating a hydrocolloid stabilizer. The results showed that the optimum amount (w/w) of oil for oleyl laurate nanoemulsions was 30 and 20 g (w/w) for oleyl stearate nanoemulsions and oleyl oleate nanoemulsions. For each nanoemulsions system, the amount of mixed surfactants and stabilizer needed for the emulsification to take place was found to be 10 and 0.5 g (w/w), respectively. The emulsification process via high-energy emulsification method successfully produced nano-sized range particles. The nanoemulsions systems passed the centrifugation test and freeze-thaw cycle with no phase failures, and stable for 3 months at various storage temperatures (3°C, 25°C and 45°C). The results proved that the prepared nanoemulsions system cannot be formed spontaneously, and thus, energy input was required to produce nano-sized range particles.
Authors:
Nursyamsyila Mat Hadzir; Mahiran Basri; Mohd Basyaruddin Abdul Rahman; Abu Bakar Salleh; Raja Noor Zaliha Raja Abdul Rahman; Hamidon Basri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-06
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  14     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-12     Revised Date:  2014-02-13    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  456-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cyclooxygenase Inhibitors / chemistry*
Emulsions*
Esters
Fatty Acids / chemistry*
Piroxicam / chemistry*
Chemical
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Emulsions; 0/Esters; 0/Fatty Acids; 13T4O6VMAM/Piroxicam
Comments/Corrections

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