| Phase behavior of ketoprofen-poly(lactic acid) drug particles formed by rapid expansion of supercritical solutions. | |
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MedLine Citation:
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PMID: 20795658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present contribution investigates whether it is possible to form stable amorphous particles of ketoprofen-poly(lactic acid), naproxen-poly(lactic acid), and indomethacin-poly(lactic acid). Amorphization and micronization of these poorly water-soluble drugs offer a combined way to improve the solubility and enhance the dissolution rate. The particles were formed by pulsed rapid expansion of supercritical CO(2) solutions and characterized in the aerosol phase with rapid-scan infrared spectroscopy and after collection with scanning electron microscopy and X-ray diffraction. None of the three drug-poly(lactic acid) mixtures showed long-term stability on the order of weeks against the reversion from the amorphous to the crystalline state. Ketoprofen was the only drug that formed mixed amorphous particles with at least short-term stability. The long-term products turned out to be submicrometer- to micrometer-sized particles with a crystalline drug core and an amorphous poly(lactic acid) shell. Moreover, we found that the poly(lactic acid) coating stabilizes the particles against agglomeration. |
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Authors:
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Muhammad Imran ul-haq; Egor Chasovskikh; Ruth Signorell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Langmuir : the ACS journal of surfaces and colloids Volume: 26 ISSN: 1520-5827 ISO Abbreviation: Langmuir Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
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Languages: eng Pagination: 14951-7 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Indomethacin
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chemistry Ketoprofen / chemistry* Kinetics Lactic Acid / chemistry* Microscopy, Electron, Scanning Naproxen / chemistry Polymers / chemistry* Solutions Spectrophotometry, Infrared |
| Chemical | |
Reg. No./Substance:
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0/Polymers; 0/Solutions; 22071-15-4/Ketoprofen; 22204-53-1/Naproxen; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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