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Phase 1 of an in vitro neurotoxicological pre-validation trial.
MedLine Citation:
PMID:  20693015     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In the absence of a formal in vitro alternative model for neurotoxicity testing, the CellTox Centre, in collaboration with the University of Salford, FRAME and the EEC, has set up an initial pre-validation trial of a three-tiered scheme that was originally proposed in 1989. Using a cell battery of neuroblastomas and primary neural cultures (Tier I) and primary astrocytes (Tier III) an initial set of 20 chemicals (out of a reference set of 40 chemicals) has been assessed for neurotoxicity using a multiple end point assay system. The methods used were relatively simple, rapid and inexpensive, and the chemical end points were easily quantified. The results of the pre-validation trial have enabled us to revise the first tier of the proposed tiered system for full micro-validation.
Authors:
S P Williams; J Davenport-Jones; C Egan; S O'Hare; M Cookson; R McClean; M J Garle; V Pentreath; C K Atterwill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology in vitro : an international journal published in association with BIBRA     Volume:  8     ISSN:  0887-2333     ISO Abbreviation:  Toxicol In Vitro     Publication Date:  1994 Aug 
Date Detail:
Created Date:  2010-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712158     Medline TA:  Toxicol In Vitro     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-802     Citation Subset:  -    
Affiliation:
CellTox Centre, Division of Biosciences, University of Hertfordshire, College Lane, Hatfield, Herts. AL10 9AB, UK.
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