| Phase 1 Results From a Study of Romidepsin in Combination With Gemcitabine in Patients With Advanced Solid Tumors. | |
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MedLine Citation:
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PMID: 22536933 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Romidepsin is a potent histone deacetylase inhibitor; preclinical studies showed potential synergy with the nucleoside analog gemcitabine. This phase 1 trial was conducted to determine the maximum tolerated dose for two schedules of romidepsin plus gemcitabine in patients with advanced solid tumors in which gemcitabine had previously demonstrated clinical activity. The recommended phase 2 dose was 12 mg/m(2) romidepsin plus 800 mg/m(2) gemcitabine on days 1 and 15 every 28 days. Results suggest additive hematologic toxicities of romidepsin plus gemcitabine, but the level of antitumor activity observed warrants more formal trials of this combination to further assess safety and efficacy. |
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Authors:
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Suzanne F Jones; Jeffrey R Infante; David R Spigel; Nancy W Peacock; Dana S Thompson; F Anthony Greco; William McCulloch; Howard A Burris Iii |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-26 |
Journal Detail:
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Title: Cancer investigation Volume: - ISSN: 1532-4192 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Sarah Cannon Research Institute, Nashville, Tennessee, USA,1. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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