Document Detail

Pharyngeal pituitary: development, malformation, and tumorigenesis.
MedLine Citation:
PMID:  10483784     Owner:  NLM     Status:  MEDLINE    
The development of the pharyngeal pituitary (PhP) in the fetal period was morphologically and, for the first time, immunohistochemically examined. PhP, found in every individual, begins its hormone production at the 17-18th week of gestation, that is, 4-8 weeks later than that of sellar pituitary (SP). Only 1 of 25 examined fetuses without any stigmata of developmental anomalies showed a residual pituitary fragment in the craniopharyngeal canal (craniopharyngeal pituitary, CPhP). An adult case of a rare clivus pituitary adenoma that we examined is demonstrated in discussing its relationship to PhP. Extracranial ectopic pituitary adenomas in the literature describe an exclusively sphenoid sinus/nasopharyngeal/clivus location of the tumor. Their location corresponded exactly with that of PhP, so that the origin of the tumors can be reasonably speculated as PhP, although another origin, e.g., CPhP, can not be excluded. A variety of malformations of PhP, although very rare, have been described for the fist time during the systemic examination of 16 fetuses with different cranioneural malformations, such as agenesis, unseparated PhP from SP (pharyngosellar pituitary), fragmentation, and residual pituitary tissue in the open craniopharyngeal canal. However, developmental anomaly of PhP was not specifically associated with cranioneural malformations except in cases of chromosomal aberrations. The hormone production in PhP in malformation cases tended to be retarded. Absence of SP was recorded in 50% of anencephalics in the literature; however, PhP was identified in all anencephalics in our series, independent of the existence of SP. This supports the opinion that agenesis of SP in anencephalics seems to be false information.
A Hori; D Schmidt; E Rickels
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta neuropathologica     Volume:  98     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-20     Completed Date:  1999-10-20     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  262-72     Citation Subset:  IM    
Institute of Neuropathology, Medizinische Hochschule Hannover, Germany.
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MeSH Terms
Adenoma / embryology*,  pathology
Anencephaly / embryology,  pathology
Choristoma / embryology*,  pathology
Embryonic and Fetal Development
Middle Aged
Pharyngeal Diseases / embryology*,  pathology
Pituitary Gland*
Pituitary Hormones / analysis
Pituitary Neoplasms / embryology*,  pathology
Reticulin / analysis
Sphenoid Sinus / embryology,  pathology
Reg. No./Substance:
0/Pituitary Hormones; 0/Reticulin

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